Use
Clometacin, an analogue of indometacin, was introduced on the
market in 1971. Subsequently several cases of severe - in some cases fatal -
hepatitis were reported, which led in 1987 to the withdrawal of a high-dosage tablet
formulation, while the indications for a lower dosage tablet were restricted and
duration of the treatment was limited. Eventually all tablet formulations were
removed from the market. Clometacin is not widely registered in other countries.