| | 162808-62-0 Basic information More.. |
| Product Name: | Caspofungin | | Synonyms: | CASPOFUNGIN;CASPORFUNGIN;PneuMocandin B0,1-[(4R,5S)-5-[(2-aMinoethyl)aMino]-N2-(10,12-diMethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-;Aids058650;Aids-058650;Cancidas (tm);m991;Caspofungin .CH3COOH | | CAS: | 162808-62-0 | | MF: | C52H88N10O15 | | MW: | 1093.31 | | EINECS: | 1806241-263-5 | | Mol File: | 162808-62-0.mol |  |
Use
Cmax 70 mg 1-h infusion: c. 10 mg/L 1 h post infusion
Plasma half-life: 9–11 h
Volume of distribution: 0.15 L/kg
Plasma protein binding: 97%
Blood concentrations increase in proportion to dosage.
Distribution
The drug is widely distributed, the highest concentrations being found in the liver. Levels in the CSF are negligible.
Metabolism and excretion
It is slowly metabolized by the liver through non-enzymatic peptide hydrolysis and N-acetylation, and the two inactive metabolites are excreted in the feces and bile. No dosage adjustment is required in patients with renal impairment; however, a dose reduction to 35 mg following the 70 mg loading dose is recommended for patients with moderate hepatic impairment. Caspofungin is not cleared by hemodialysis.
- Caspofungin
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- US $0.00-0.00 / Kg/Drum
- 2024-09-18
- CAS:162808-62-0
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 500kg
- Caspofungin
-
- US $0.00-0.00 / KG
- 2024-08-26
- CAS:162808-62-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500KG
- Caspofungin
-
- US $1.10 / g
- 2024-04-17
- CAS:162808-62-0
- Min. Order: 1g
- Purity: 99.0% min
- Supply Ability: 100 tons min
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162808-62-0
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