| | 64925-80-0 Basic information More.. |
| Product Name: | PHOMOPSIN A | | Synonyms: | phomopsin a from phomopsis leptostromiformis;phomopsin;PHOMOPSIN A;PMSA;Phomopsin A, 98%, from Phomopsis leptostromiformis;Aspartic acid, (βS)-3-chloro-β,5-dihydroxy-N-methyl-L-tyrosyl-3,4-didehydro-L-valyl-3-hydroxy-L-isoleucyl-3,4-didehydro-L-prolyl-(2E)-2,3-didehydroisoleucyl-2,3-didehydro-, cyclic (15→3)-ether, (2E)- | | CAS: | 64925-80-0 | | MF: | C36H45ClN6O12 | | MW: | 789.23 | | EINECS: | | | Mol File: | 64925-80-0.mol |  |
Use
Phomopsin A is a an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an ‘ansa’ macrocycle with a tripeptide tail, terminating in a dicarboxylic acid. Phomopsin A is a potent mycotoxin produced by the fungus, Phomopsis leptostromiformis, and causes lupinosis in livestock fed infected lupins. Phomopsin A is an important bioprobe for understanding cellular structural proteins. It binds selectively to dimeric tubulin at a site overlapping that of vinblastine and maytansine, inhibiting the formation of the microtubule spindle to block cell division. Uniquely, phomopsin A protects tubulin from decay.
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64925-80-0
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