| | 2068-78-2 Basic information More.. |
| Product Name: | Vincristine sulfate | | Synonyms: | VINCRISTINE SULFATE;VINCRISTINE SULFATE, APOCYNACEAE SPECIES;VCR, LEUKOCRISTINE SULFATE;VCR SULFATE;Vincristine，Leurocristine，Oncovin，Vinblastine;Vincristin Sulfate;Vincristine sulfate,95%;Vincaleukoblastine, 22-oxo-, sulfate (1:1) | | CAS: | 2068-78-2 | | MF: | C46H58N4O14S | | MW: | 923.04 | | EINECS: | 218-190-0 | | Mol File: | 2068-78-2.mol |  |
Use
Vincristine sulfate is available as a 1-mg/mL solution in 1-,2-, and 5-mL vials for IV administration in acute leukemiaand as part of a multidrug regime for Hodgkin’s and neuroblastoma, Ewing sarcoma, Wilms tumor, soft tissuesarcoma, testicular cancer, liver cancer, and head and neckcancers. It has also been utilized in treating pediatric cancer.Vincristine is highly protein bound (75%) and may also bindto platelets that contain large amounts of tubulin. Numerousmetabolites have been detected and several have been identified,one of which is the 4-O-desacetyl derivative. The metabolismthat does occur is believed to largely be mediatedby CYP3A. Elimination occurs primarily in the bile with aterminal elimination half-life of 23 to 85 hours. The mostcommonly seen toxicity for vincristine is a dose-limitingneurotoxicity caused by effects on axonal microtubules.Symptoms are variable and include peripheral neuropathy,ataxia, seizure, bone pain, and coma. Constipation is also acommonly seen toxicity, and laxatives may be used prophylactically.Other toxicities include alopecia, skin rash, mildmyelosuppression, secretion of antidiuretic hormone,azospermia, and amenorrhea.
- Vincristine sulfate
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- US $10.00 / kg
- 2024-04-22
- CAS:2068-78-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000 tons
- Vincristine Sulfate
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- US $1.00 / mg
- 2024-04-15
- CAS:2068-78-2
- Min. Order: 100mg
- Purity: 0.99
- Supply Ability: 5ton/month
- Vincristine Sulfate
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- US $0.00 / kg
- 2024-04-12
- CAS:2068-78-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 2000ton
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2068-78-2
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