ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Suppliers list
Company Name: Xinxiang Hongqi District Houyuan Trading Co.,Ltd
Tel: +86-0373-3695376 +86-13937349994
Email: HYJM@houyuanjm.com
Products Intro: Product Name:3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER
CAS:769195-26-8
Purity:99.0% up Package:25Kg;0.00;USD
Company Name: Henan Fengda Chemical Co., Ltd
Tel: +8613613820652
Email: info@fdachem.com
Products Intro: Product Name: Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
CAS:769195-26-8
Purity:99% Package:1KG;5USD|1000KG;0.1USD
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
Tel: +86-371-66670886
Email: info@dakenam.com
Products Intro: Product Name:3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER
CAS:769195-26-8
Purity:99% Package:100g ;1KG ;5KG 25KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
CAS:769195-26-8
Purity:99% Package:25KG;5KG;1KG
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070
Email: product@chemlin.com.cn
Products Intro: CAS:769195-26-8
Purity:98% Package:g-Kg Remarks:White solid

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate manufacturers

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Basic information
Product Name:Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
Synonyms:3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER;2,4,5-TRIFLUORO-BETA-OXO-BENZENEBUTANOIC ACID METHYL ESTER;Methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate;4-(2,4,5 )triflorophenyl 3-oxobutanoic acid, Methy ester;3-oxo-4-(2,4,5-trifluorophenyl;Benzenebutanoicacid,2,4,5-trifluoro-b-oxo-,Methylester;Methyl 2,4,5-trifluoro-b-oxo-benzenebutanoate;Methyl 3-oxo-4-(2,4,5-trifluorophenyl)
CAS:769195-26-8
MF:C11H9F3O3
MW:246.19
EINECS:1308068-626-2
Product Categories:
Mol File:769195-26-8.mol
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Structure
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Chemical Properties
Melting point 40-41 °C
Boiling point 273.3±35.0 °C(Predicted)
density 1.330±0.06 g/cm3(Predicted)
refractive index 1.469
Fp 115.5±20.8 °C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka9.95±0.46(Predicted)
color Pale Yellow to Light Yellow
Safety Information
HS Code 2918300090
MSDS Information
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate Usage And Synthesis
Chemical PropertiesOff-white solid
UsesMethyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is a useful synthetic intermediate in the synthesis of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase (DPP) IV inhibitor for the treatment of type II diabetes.
PreparationThe preparation of methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is as follows:Stage 1: (2,4,5-trifluorophenyl)acetic acid With 1,1'-carbonyldiimidazole In acetonitrile for 3.5h;Stage 2: monomethyl monopotassium malonate With triethylamine; magnesium chloride In acetonitrile at 50℃; for 8h;Stage 3: In acetonitrile at 30℃; for 26h.
Tag:Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate(769195-26-8) Related Product Information
Succinylcholine Chloride Acarbose Ethambutol Paroxetine Sitagliptin N-Phoshate IMpurity (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one Sitagliptin phosphate Sitagliptin Impurity 31 Sitagliptin impurity H HCl Sitagliptin Impurity 34 (S)-Sitagliptin Phosphate Sitagliptin Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate 2,4,5-TRIFLUOROBENZYL CHLORIDE 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate