- Trimethylboroxine
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- $0.00 / 1kg
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2024-08-15
- CAS:823-96-1
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 10 tons
- Trimethylboroxine
-
- $6.00 / 1kg
-
2024-08-08
- CAS:823-96-1
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 100000
- Trimethylboroxine
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- $100.00 / 1KG
-
2023-12-26
- CAS:823-96-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| Trimethylboroxine Basic information |
Product Name: | Trimethylboroxine | Synonyms: | 2,4,6-Trimethyl-cyclotriboroxane;Boroxin, 2,4,6-trimethyl-;2,4,6-Trimethyl-1,3,5-trioxa-2,4,6-triboracyclohexane;Methaneboronic anhydride;Methylboric anhydride;Trimethylboroxine, 3.5M (50 wt.%) solution in THF;Trimethylboroxine, 3.5M (50 wt.%) solution in THF, AcroSeal;2,5,6-triMethyl-6H-1,3-oxaborinine | CAS: | 823-96-1 | MF: | C3H9B3O3 | MW: | 125.53 | EINECS: | | Product Categories: | API intermediates;Boronic Acids and Derivatives;Organometallic Reagents;Others | Mol File: | 823-96-1.mol | |
| Trimethylboroxine Chemical Properties |
Melting point | −38 °C(lit.) | Boiling point | 78-80 °C(lit.) | density | 0.898 g/mL at 25 °C(lit.) | refractive index | n20/D 1.362(lit.) | Fp | 16 °F | storage temp. | Flammables area | solubility | Chloroform (Sparingly), Dichloromethane (Slightly), THF (Soluble) | form | Solution | color | Colorless to yellow | Water Solubility | Not miscible in water. | Sensitive | Moisture Sensitive & Hygroscopic | BRN | 1757008 | Exposure limits | ACGIH: TWA 50 ppm; STEL 100 ppm (Skin) OSHA: TWA 200 ppm(590 mg/m3) NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) | InChIKey | GBBSAMQTQCPOBF-UHFFFAOYSA-N | CAS DataBase Reference | 823-96-1(CAS DataBase Reference) |
| Trimethylboroxine Usage And Synthesis |
Chemical Properties | colorless to yellow solution | Uses | Trimethylboroxine (TMB) is a cyclic anhydride of methyl-boronic acid. It can be used as a:
- Methylating agent for the methylation of various aromatic halides and C(sp3)?H bonds using palladium catalyst.
- Reagent in the preparation of polymer supported CBS (Corey, Bakshi, and Shibata) catalysts.
| Uses | Trimethylboroxine (TMB) is a cyclic anhydride of methyl-boronic acid. It can be been used:
- As a derivatizing agent for gas chromatographic/mass spectrometric analysis.
- In the preparation of methylaluminoxane (MAO) which is used in the polymerization of olefins.
- As an electrolyte additive to enhance the interface stability of electrode/electrolyte.
- In methylation of aryl halides by palladium-catalyzed Suzuki-Miyaura coupling reaction.
- In the preparation of CBS (Corey, Bakshi and Shibata) catalysts for asymmetric reductions of ketones to alcohols.
| Uses | Trimethylboroxine is used as a derivatizing agent for GLC analysis. It is used in a diverse array of areas, including as a polymerization additive. It is also used in the preparation of CBS catalysts for asymmetric reductions. | Preparation |
Trimethylboroxine is prepared by heating B(CH3)3 and B2O3 together in a sealed tube. The B2O3 powder is made by dehydrating H3BO3 under vacuum over P2O5 , at 220℃. The very hygro-scopic oxide is placed with strict exclusion of moisture in a 200-ml. thick-wall Pyrex tube provided with a ground joint, and a melting-point capillary is fastened to the tube just below the joint. The tube is connected to a vacuum pump and immersed in liquid nitrogen, and when a high vacuum has been established, a quantity of B(CH3)3 equivalent to 4.25 g. (0.061 mole) of B2O3 is condensed in the tube. The tube is sealed off, heated to 600℃ and kept at this temperature for six hours; in the process the contents turn into a clear, colorless liquid. When the tube has cooled down, the tip is broken under a nitrogen blanket and sealed to a tube leading to the vacuum pump. The tube is evacuated and the contents of the tube are transferred into a -78℃ trap. The crude product is purified by removing volatile contaminants at -45℃ and then distilling the product from a -10℃ trap into a receiver held at -78℃.
| Application | Trimethylboroxine (TMB) is a cyclic anhydride of methyl-boronic acid. It can be been used: As a derivatizing agent for gas chromatographic/mass spectrometric analysis. In the preparation of methylaluminoxane (MAO) which is used in the polymerization of olefins. As an electrolyte additive to enhance the interface stability of electrode/electrolyte. In methylation of aryl halides by palladium-catalyzed Suzuki-Miyaura coupling reaction. In the preparation of CBS (Corey, Bakshi and Shibata) catalysts for asymmetric reductions of ketones to alcohols. | Purification Methods | Possible impurity is methylboronic acid. If present, then add a few drops of conc H2SO4 and distil it immediately, then fractionate it through an efficient column. [McCusker et al. J Am Chem Soc 79 5179 1957, IR: Goubeau & Keller Z Anorg Allgem Chem 272 303 1953, Beilstein 4 IV 4378.] | Structure and conformation | The B and O atoms in trimethylboroxine form a symmetrical six-membered ring.
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| Trimethylboroxine Preparation Products And Raw materials |
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