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| | 1-BROMO-4-FLUORO-2-NITROBENZENE Basic information |
| | 1-BROMO-4-FLUORO-2-NITROBENZENE Chemical Properties |
| Melting point | 37-39°C | | Boiling point | 148-150°C 35mm | | density | 1.808±0.06 g/cm3(Predicted) | | Fp | 148-150°C/35mm | | storage temp. | Sealed in dry,Room Temperature | | form | powder to lump to clear liquid | | color | White or Colorless to Yellow to Green | | BRN | 2364227 | | InChI | InChI=1S/C6H3BrFNO2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H | | InChIKey | XRXNWKIKQFEOGO-UHFFFAOYSA-N | | SMILES | C1(Br)=CC=C(F)C=C1[N+]([O-])=O | | CAS DataBase Reference | 446-09-3(CAS DataBase Reference) |
| Provider | Language |
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ALFA
| English |
| | 1-BROMO-4-FLUORO-2-NITROBENZENE Usage And Synthesis |
| Chemical Properties | light yellow powder | | Synthesis | General procedure for the synthesis of 2-bromo-5-fluoronitrobenzene from 2-nitro-4-fluorobenzoic acid: 6.2 mg of silver sulfate, 36.3 mg of copper acetate, 12.5 mg of 2,9-dimethyl-1,10-o-phenanthroline, 37 mg of 2-nitro-4-fluorobenzoic acid, and 30.9 mg of sodium bromide were sequentially added to a Silak reactor tube fitted with a magnetic stirrer, followed by 4 mL of dimethyl sulfoxide as solvent. The reaction mixture was heated to 160°C under an oxygen atmosphere with continuous stirring for 24 hours. Upon completion of the reaction, distilled water was added to the reaction mixture to quench the reaction, followed by extraction with ethyl acetate three times at 10 mL each. the organic phases were combined, and 21.1 mg of 2-bromo-5-fluoronitrobenzene was obtained after concentration in 48% yield. | | References | [1] Journal of Organic Chemistry, 2016, vol. 81, # 7, p. 2794 - 2803
[2] Patent: CN107325002, 2017, A. Location in patent: Paragraph 0067
[3] Organic and Biomolecular Chemistry, 2018, vol. 16, # 30, p. 5416 - 5421 |
| | 1-BROMO-4-FLUORO-2-NITROBENZENE Preparation Products And Raw materials |
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