| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
|
| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:LMTK3-IN-1
CAS:2764850-23-7
Purity:98% Package:5mg Remarks:S34193
|
| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:LMTK3 inibitor C28
CAS:2764850-23-7
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
|
LMTK3 inibitor C28 manufacturers
- LMTK3-IN-1
-
- $30.00 / 1mg
-
2025-06-05
- CAS:2764850-23-7
- Min. Order:
- Purity: 100%
- Supply Ability: 10g
|
| | LMTK3 inibitor C28 Basic information |
| Product Name: | LMTK3 inibitor C28 | | Synonyms: | LMTK3 inibitor C28;LMTK3-IN-1;6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine;4-{3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-yl}pyridine | | CAS: | 2764850-23-7 | | MF: | C18H11F3N4O | | MW: | 356.31 | | EINECS: | | | Product Categories: | | | Mol File: | 2764850-23-7.mol |  |
| | LMTK3 inibitor C28 Chemical Properties |
| storage temp. | -10 to -25°C | | solubility | Soluble to 50 mM in DMSO and to 20 mM in ethanol | | form | Solid | | color | Light yellow to yellow |
| | LMTK3 inibitor C28 Usage And Synthesis |
| Uses | LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM[1]. | | Biological Activity | C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα. | | storage | Store at -20°C | | References | [1] Agnarelli A, et al. The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. Int J Mol Sci. 2023 Jan 3;24(1):865. DOI:10.3390/ijms24010865 |
| | LMTK3 inibitor C28 Preparation Products And Raw materials |
|