| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Neuraminidase-IN-10
CAS:2685786-29-0
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
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1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-3-(1-ethylpropoxy)-5-[[[2-methoxy-4-(2-thienyl)phenyl]methyl]amino]-, (3R,4R,5S)- manufacturers
- Neuraminidase-IN-10
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- $1980.00 / 50mg
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2025-10-27
- CAS:2685786-29-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-3-(1-ethylpropoxy)-5-[[[2-methoxy-4-(2-thienyl)phenyl]methyl]amino]-, (3R,4R,5S)- Basic information |
| | 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-3-(1-ethylpropoxy)-5-[[[2-methoxy-4-(2-thienyl)phenyl]methyl]amino]-, (3R,4R,5S)- Chemical Properties |
| Boiling point | 686.8±55.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | pka | 4.10±0.60(Predicted) |
| | 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-3-(1-ethylpropoxy)-5-[[[2-methoxy-4-(2-thienyl)phenyl]methyl]amino]-, (3R,4R,5S)- Usage And Synthesis |
| Uses | Neuraminidase-IN-10 is a potent neuraminidase (NA) inhibitor with ?anti-influenza?activity. Neuraminidase-IN-10 is against H1N1, H5N1, and H5N8 with IC50 values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively[1]. | | in vivo | Neuraminidase-IN-10 (0.156 mM-10 mM; injected into the eggs) showed good protection against both H5N1 and H5N8 strains in a dose-dependent manner in a chicken embryonated egg model [1]. | Animal Model: | SPF Chicken Embryonated Egg[1] | | Dosage: | 0.156 mM; 0.625 mM; 2.5 mM; 10 mM | | Administration: | Injected into the egg | | Result: | were not as effective as OSC in this infection model, but also exhibited a certain therapeutic effect.The survival rates of?Neuraminidase-IN-10?(H5N1: 100 and 40%, respectively; H5N8: 100 and 100%, respectively)? at 2.5 mM and 10 mM[1]. |
| | References | [1] Han Ju, et al. Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity. J Med Chem. 2022 Aug 8. doi: 10.1021/acs.jmedchem.1c01970. DOI:10.1021/acs.jmedchem.1c01970 |
| | 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-3-(1-ethylpropoxy)-5-[[[2-methoxy-4-(2-thienyl)phenyl]methyl]amino]-, (3R,4R,5S)- Preparation Products And Raw materials |
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