| Company Name: |
Bide Pharmatech Ltd.
|
| Tel: |
400-1647117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:N-((1S,2S)-2-(4-(2-Methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide
CAS:2563870-87-9
Purity:98% Package:5mg;10mg;25mg;50mg;100mg Remarks:BD02202008
|
| Company Name: |
Suzhou Zhixin Biotechnology Co., Ltd.
|
| Tel: |
0512-65118909 18100677375 |
| Email: |
sales@szzxbio.com |
| Products Intro: |
Product Name:(1S,2S)-ML-SI3
CAS:2563870-87-9
Purity:98%+ Package:1g;10g;100g
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:(1S,2S)-ML-SI3
CAS:2563870-87-9
Package:10mg;50mg
|
|
| | Benzenesulfonamide, N-[(1S,2S)-2-[4-(2-methoxyphenyl)-1-piperazinyl]cyclohexyl]- Basic information |
| | Benzenesulfonamide, N-[(1S,2S)-2-[4-(2-methoxyphenyl)-1-piperazinyl]cyclohexyl]- Chemical Properties |
| Boiling point | 589.3±60.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | pka | 11.63±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | Benzenesulfonamide, N-[(1S,2S)-2-[4-(2-methoxyphenyl)-1-piperazinyl]cyclohexyl]- Usage And Synthesis |
| Uses | (1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM)[1]. | | IC 50 | TRPML1: 5.9 μM (IC50); TRPML2: 2.7 μM (EC50); TRPML3: 10.8 μM (EC50) | | References | [1] Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966. DOI:10.1016/j.ejmech.2020.112966 |
| | Benzenesulfonamide, N-[(1S,2S)-2-[4-(2-methoxyphenyl)-1-piperazinyl]cyclohexyl]- Preparation Products And Raw materials |
|