2'-cyano-2'-deoxyarabinofuranosylcytosine

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2'-cyano-2'-deoxyarabinofuranosylcytosine Basic information
Product Name:2'-cyano-2'-deoxyarabinofuranosylcytosine
Synonyms:2'-cyano-2'-deoxyarabinofuranosylcytosine;CNDAC HCl salt;2'-Cyano-2'-deoxyarabinofuranosylcytosine hydrochloride;1-(2-C-cyano-2-deoxy-β-D-arabinofuranosyl)cytosine hydrochloride;TAS-109 Hydrochloride;TAS109;TAS 109;DFP-10917 HYDROCHLORIDE; TAS-109 HYDROCHLORIDE;CNDAC;TAS109;TAS 109
CAS:134665-72-8
MF:C10H12N4O4.ClH
MW:288.69
EINECS:
Product Categories:
Mol File:134665-72-8.mol
2'-cyano-2'-deoxyarabinofuranosylcytosine Structure
2'-cyano-2'-deoxyarabinofuranosylcytosine Chemical Properties
storage temp. Store at -20°C
solubility DMSO: 125 mg/mL (432.99 mM)
form Solid
color White to off-white
Safety Information
MSDS Information
2'-cyano-2'-deoxyarabinofuranosylcytosine Usage And Synthesis
UsesCNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis[1][2].
in vivo

CNDAC (20mg/kg; i.p.; daily for 10 days) shows antitumor activity in mice[4].

Animal Model:CDF1 mice, P388 tumor model[4]
Dosage:20 mg/kg
Administration:Intraperitoneal injection, daily for 10 days
Result:Greatly increased the survival time and survival rate.
References[1] Liu XJ, et al. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer. 2012 Aug;31(8):373-80. DOI:10.5732/cjc.012.10077
[2] Jagan S, et al. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Adv Hematol. 2012;2012:727683. DOI:10.1155/2012/727683
[3] Serova M, et al. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells. Br J Cancer. 2007 Sep 3;97(5):628-36. DOI:10.1038/sj.bjc.6603896
[4] Azuma A, et al. Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum. J Med Chem. 1993 Dec 24;36(26):4183-9. DOI:10.1021/jm00078a006
2'-cyano-2'-deoxyarabinofuranosylcytosine Preparation Products And Raw materials
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