| Company Name: |
Shanghai meikai technology co., ltd
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| Tel: |
021-68689288 15300790979 |
| Email: |
info@mkbio.com.cn |
| Products Intro: |
Product Name:Monarsen(Synonyms:EN101;ODN7040;BL7040)
CAS:864021-55-6
Purity:98% Package:100mg;250mg;1g
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| | BL7040) Basic information |
| Product Name: | BL7040) | | Synonyms: | BL7040);Monarsen(Synonyms:EN101;ODN7040 | | CAS: | 864021-55-6 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![BL7040) Structure]() |
| | BL7040) Chemical Properties |
| Sequence | DNA, d(C-T-G-C-G-A-T-A-T-T-T-T-C-T-T-G-T-rAm-rCm-rCm) |
| | BL7040) Usage And Synthesis |
| Uses | Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR). | | IC 50 | AChE | | References | [1] Sussman JD, Argov Z, McKee D, Hazum E, Brawer S, Soreq H. Antisense treatment for myasthenia gravis: experience with monarsen. Ann N Y Acad Sci. 2008;1132:283-290. DOI:10.1196/annals.1405.022
[2] Evron T, Moyal-Segal LB, Lamm N, Geffen A, Soreq H. RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons. Neurodegener Dis. 2005;2(1):16-27. DOI:10.1159/000086427
[3] Kehat R, Zemel E, Cuenca N, et al. A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress. Invest Ophthalmol Vis Sci. 2007;48(3):1290-1297. DOI:10.1167/iovs.06-0847 |
| | BL7040) Preparation Products And Raw materials |
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