小白菊内酯衍生物
中文名称 | 小白菊内酯衍生物 |
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中文同义词 | 阿格拉宾;小白菊内酯衍生物;阿格拉宾, BR;阿格拉宾ARGLABIN;化合物TRIAPINE;ARGLABIN(阿格拉宾) |
英文名称 | arglabin |
英文同义词 | (3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one;arglabin;(3aR,4aS)-1,4aα-Dimethyl-7-methylene-4a,5,6,6aα,9aβ,9bα-hexahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(7H)-one;(3aS)-2,3,3aβ,4,5β,6,6a,7,9aβ,9bα-Decahydro-6α,6aα-epoxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2-one;3H-Oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one, 5,6,6a,7,9a,9b-hexahydro-1,4a-diMethyl-7-Methylene-, [4aS-(3aS*,4aα,6aα,9aβ,9bα)]-;Arglabine;3H-Oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one,5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-, (3aR,4aS,6aS,9aS,9bR);Arglabin 84692-91-1 |
CAS号 | 84692-91-1 |
分子式 | C15H18O3 |
分子量 | 246.3 |
EINECS号 | |
相关类别 | 标准品;对照品-中药对照品;倍半萜 |
Mol文件 | 84692-91-1.mol |
结构式 |
小白菊内酯衍生物 性质
熔点 | 100-102 °C |
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沸点 | 404.6±45.0 °C(Predicted) |
密度 | 1.22±0.1 g/cm3(Predicted) |
储存条件 | Amber Vial, -20°C Freezer, Under inert atmosphere |
溶解度 | 可溶于氯仿(少许) |
形态 | 固体 |
颜色 | 米白色 |
The antitumor activity of arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene, a process that is believed to play a pivotal role in 20-30% of all human tumors. It actually inhibits the incorporation of farnesyl pyrophosphate into human H-ras proteins by the enzyme farnesyl transferase (FTase).
Arglabin reduces inflammation and plasma lipids, increases autophagy, and orients tissue macrophages into an anti-inflammatory phenotype in ApoE2.Ki mice fed a high-fat diet.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-16059 | Arglabin | 1 mg | 1173元 | |
2024/04/30 | HY-16059 | 小白菊内酯衍生物 Arglabin | 84692-91-1 | 10mM * 1mLin DMSO | 3178元 |