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Ibudilast

Ibudilast Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Ibudilast
CAS:50847-11-5
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:50847-11-5
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Ibudilast
CAS:50847-11-5
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
Email: product@chemlin.com.cn
Products Intro: CAS:50847-11-5
Purity:98% Package:g-Kg Remarks:White powder
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:Ibudilast
CAS:50847-11-5
Purity:98% HPLC LCMS Package:10G;20G

Lastest Price from Ibudilast manufacturers

  • Ibudilast
  • US $1.00 / kg
  • 2019-05-13
  • CAS:50847-11-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: Customized
  • Ibudilast
  • US $10.00 / KG
  • 2019-04-30
  • CAS:50847-11-5
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5000kg/month
Ibudilast Basic information
Product Name:Ibudilast
Synonyms:2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine;2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE;3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE;Ibudilast 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine;2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one;Ibudilast, >=98%;budilast;1-propanone 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine KC-404
CAS:50847-11-5
MF:C14H18N2O
MW:230.31
EINECS:637-150-7
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cyclic Nucleotide related;Amines;Heterocycles;API
Mol File:50847-11-5.mol
Ibudilast Structure
Ibudilast Chemical Properties
Melting point 53-54°C
Boiling point 175°C/7.5mmHg(lit.)
density 1.09
refractive index 1.5500 (estimate)
storage temp. 2-8°C
solubility DMSO: 28 mg/mL, soluble
form solid
color white
Merck 14,4879
InChIKeyZJVFLBOZORBYFE-UHFFFAOYSA-N
CAS DataBase Reference50847-11-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS UR0711200
ToxicityLD50 i.v. in mice: 260 mg/kg (Irikura, 1973)
Ibudilast Usage And Synthesis
DescriptionIbudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.
Chemical PropertiesWhite Solid
OriginatorKyorin (Japan)
Usesa phosphodiesterase inhibitor with anti-inflammatory activity
UsesInhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]
UsesA leukotriene D4 antagonist. Used as an antiallergic, antiasthmatic, and vasodilator (cerebral)
Brand nameKetas
Biological ActivityPhosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.
Ibudilast Preparation Products And Raw materials
Raw materialsSodium acetate-->2-Picoline-->Isobutyric anhydride
Tag:Ibudilast(50847-11-5) Related Product Information
Ibudilast Bensulfuron methyl Citric acid monohydrate Parathion-methyl Kresoxim-methyl Thiophanate-methyl ULINASTATIN Cefazolin 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Methylparaben Cilastatin Imipenem-Cilastatin sodium hydrate Methyl Methyl bromide Methyl acrylate Isobutyryl chloride Naphazoline hydrochloride METHYL THIOPHENE-2-CARBOXYLATE