| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Apoptosis inducer 25
CAS:2763063-15-4
Package:50mg/RMB 16800
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| | Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, 4-[(4-hydroxybenzoyl)oxy]butyl ester Basic information |
| | Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, 4-[(4-hydroxybenzoyl)oxy]butyl ester Chemical Properties |
| Boiling point | 781.6±60.0 °C(predicted) | | density | 1.22±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 8.19±0.15(predicted) |
| | Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, 4-[(4-hydroxybenzoyl)oxy]butyl ester Usage And Synthesis |
| Uses | Apoptosis inducer 25 (Compound 4H) inhibits the proliferation of cell BGC-823 with IC50 of 0.37 μM. Apoptosis inducer 25 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 25 exhibits good pharmacokinetic properties in rats[1]. | | References | [1] Li N, et al., New CDDO Arylboronate Ester Derivatives with High Selectivity and Low Toxicity. J Med Chem. 2024 Aug 22;67(16):14329-14344. DOI:10.1021/acs.jmedchem.4c01160 |
| | Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, 4-[(4-hydroxybenzoyl)oxy]butyl ester Preparation Products And Raw materials |
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