| Company Name: |
Shanghai meikai technology co., ltd
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| Tel: |
021-68689288 15300790979 |
| Email: |
info@mkbio.com.cn |
| Products Intro: |
Product Name:Autophagy-IN-1;Carbamicacid,N-[(3E,3aS,8bR)-3-[[[(2R)-2,5-Dihydro-3,4-dimethyl-5-oxo-2-furanyl]oxy]methylene]-3,3a,4,8b-tetrahydro-2-oxo-2H-indeno[1,2-b]furan-7-yl]-,1,1-dimethylethylester
CAS:3031485-19-2
Purity:98% Package:50mg/4500;100mg/7000;500mg/30000
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| | Autophagy-IN-1 Basic information |
| Product Name: | Autophagy-IN-1 | | Synonyms: | Carbamicacid,N-[(3E,3aS,8bR)-3-[[[(2R)-2,5-Dihydro-3,4-dimethyl-5-oxo-2-furanyl]oxy]methylene]-3,3a,4,8b-tetrahydro-2-oxo-2H-indeno[1,2-b]furan-7-yl]-,1,1-dimethylethylester | | CAS: | 3031485-19-2 | | MF: | C23H25NO7 | | MW: | 427.45 | | EINECS: | | | Product Categories: | | | Mol File: | 3031485-19-2.mol |  |
| | Autophagy-IN-1 Chemical Properties |
| Boiling point | 593.9±50.0 °C(predicted) | | density | 1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 13.67±0.20(predicted) | | form | Solid | | color | White to off-white |
| | Autophagy-IN-1 Usage And Synthesis |
| Uses | Autophagy-IN-1 is a potent autophagy/mitophagy inhibitor, acts by selectively increasing the autophagic flux while blocking the autophagosome-lysosome fusion in cancer cells. Autophagy-IN-1 can induce apoptosis and cell cycle arrest. Autophagy-IN-1 significantly inhibits tumor growth in an HCT116 xenograft mouse model and with low toxicity. Autophagy-IN-1 can be used for researching colorectal cancer[1]. | | in vivo | Autophagy-IN-1 (50 and 100 mg/kg; IP, daily for 15 days) significantly inhibits tumor growth in an HCT116 xenograft mouse model[1]. | Animal Model: | Male BALB/c nude mice[1] | | Dosage: | 50 and 100 mg/kg | | Administration: | IP, daily for 15 days | | Result: | Significantly inhibited tumor growth and did not observe weight loss. |
| | References | [1] Yang ST, et al. Development of Strigolactones as Novel Autophagy/Mitophagy Inhibitors against Colorectal Cancer Cells by Blocking the Autophagosome-Lysosome Fusion. J Med Chem. 2022 Jul 19. DOI:10.1021/acs.jmedchem.2c00275 |
| | Autophagy-IN-1 Preparation Products And Raw materials |
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