| Company Name: |
MedChemexpress LLC
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021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:ZD8321
CAS:182073-77-4
Purity:1940RMB/1mg Package:>98%
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| Company Name: |
BOC Sciences
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| Tel: |
|
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:ZD8321
CAS:182073-77-4
Remarks:ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) (Ki= 13±1.7 nM), suppressing adhesion of neutrophils to TNFa-activated endothelial cells. That of cancer cells with high intracellular el
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N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE manufacturers
- ZD8321
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- $1520.00 / 25mg
-
2024-10-28
- CAS:182073-77-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE Basic information |
| | N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE Chemical Properties |
| Boiling point | 573.9±50.0 °C(Predicted) | | density | 1.232±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 11.22±0.46(Predicted) | | color | Light yellow to yellow |
| | N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE Usage And Synthesis |
| Uses | ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki of 13±1.7 nM. | | Biological Activity | ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki value of 13±1.7 nM. | | in vitro | TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. | | target | Ki: 13±1.7 nM (Neutrophil elastase) | | References | [1] Veale CA, et al. Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase. J Med Chem. 1997 Sep 26;40(20):3173-81. DOI:10.1021/jm970250z
[2] Nozawa F, et al. Elastase activity enhances the adhesion of neutrophil and cancer cells to vascular endothelial cells. J Surg Res. 2000 Dec;94(2):153-8. DOI:10.1006/jsre.2000.6002 |
| | N''-[N-METHOXYCARBONYL-L-VALYL]-N-[(S)-3,3,3-TRIFLUOR-1-ISOPROPYL-2-OXOPROPYL]-L-PROLINAMIDE Preparation Products And Raw materials |
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