原卟啉二氯化锡(IV)
| 中文名称 | 原卟啉二氯化锡(IV) |
|---|---|
| 中文同义词 | 锡原卟啉IX二氯乙烷;原卟啉二氯化锡(IV);锡(IV) 卟啉 IX 二氯;锡原卟啉IX;化合物 T13161;原卟啉IX二氯化锡(IV) |
| 英文名称 | TIN PROTOPORPHYRIN IX DICHLORIDE |
| 英文同义词 | tin protoporphyrin IX;TINPROTOPORPHYRIN;Nsc267099;Stannate(2-) dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid];Tin Protoporphyrin IX (chloride);TIN PROTOPORPHYRIN IX DICHLORIDE;SnPPIX;Tin protoporphyrin I |
| CAS号 | 14325-05-4 |
| 分子式 | C34H36Cl2N4O4Sn |
| 分子量 | 754.29 |
| EINECS号 | |
| 相关类别 | Porphyrins |
| Mol文件 | 14325-05-4.mol |
| 结构式 |  |
原卟啉二氯化锡(IV) 性质
| 储存条件 | Store at RT |
|---|---|
| 溶解度 | 1eq 中可溶解至 25 mM。 NaOH 和 5 mM DMSO 溶液 |
| 形态 | 深红色至紫色固体。 |
Tin-protoporphyrin IX (SnPPIX) 是有效的血红素加氧酶-1 (HO-1) 抑制剂。 Tin-protoporphyrin IX (SnPPIX) 使 PDAC 管腺癌肿瘤对化疗敏感。
IC50: Heme oxygenase-1 (HO-1)
Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM.
Cell Viability Assay
| Cell Line: | Capan-1, CD18/HPAF, PDAC cells |
| Concentration: | 20 μM, 50 μM |
| Incubation Time: | 24 or 72 hours |
| Result: | Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM. |
Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.
| Animal Model: | Male and female athymic nude mice with PDAC cell-derived xenograft tumors |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20 |
| Result: | Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine). |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101194 | 原卟啉二氯化锡(IV) Tin-protoporphyrin IX | 14325-05-4 | 5mg | 2500元 |
| 2024/04/30 | HY-101194 | 原卟啉二氯化锡(IV) Tin-protoporphyrin IX | 14325-05-4 | 10mg | 3200元 |