锌原卟啉
| 中文名称 | 锌原卟啉 |
|---|---|
| 中文同义词 | 原卟啉 IX 锌(II) 络合物;三水合原卟啉锌,96%;锌原卟啉;三水合原卟啉锌;原卟啉锌;原卟啉锌(II);3,3'-(3,8,13,17-四甲基-7,12-二乙烯基卟啉-2,18-二基)二丙酸锌;锌原卟啉(ZNPPIX) |
| 英文名称 | PROTOPORPHYRINATO ZINC |
| 英文同义词 | PROTOPORPHYRINATO ZINC;dihydrogen [3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-N21,N22,N23,N24]zincate(4-);Zinc protoporphyrin trihydrate;Zinc protoporphyrin trihydrate, 95+%;Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem;PROTOPORPHYRINATO ZINC ISO 9001：2015 REACH;Zinc Protoporphyrin IX DISCONTINUED, offer Z439970;ZnPP |
| CAS号 | 15442-64-5 |
| 分子式 | C34H31N4O4Zn- |
| 分子量 | 625.03 |
| EINECS号 | 239-455-7 |
| 相关类别 | 天然卟啉及其衍生物;Natural Porphyrins and Derivitives;Porphyrins;metal porphine (porphyrin) complex |
| Mol文件 | 15442-64-5.mol |
| 结构式 |  |
锌原卟啉 性质
| RTECS号 | ZG9210300 |
|---|---|
| 储存条件 | Inert atmosphere,2-8°C |
| 溶解度 | DMSO：50 mg/mL（79.87 mM；需要超声波）H2O：< 0.1 mg/mL（不溶） |
| 形态 | 结晶 |
| 颜色 | 暗红色至紫色 |
| 水溶解性 | Insoluble in water. Soluble in ethanol, and DMSO, pyridine, or dimethyl formamide. |
| 稳定性 | 吸湿性 |
| EPA化学物质信息 | Zincate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-4-2)- (15442-64-5) |
|
Human Endogenous Metabolite
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Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h.
Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells.
Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.
Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3.
Apoptosis Analysis
| Cell Line: | C-26 cells |
| Concentration: | 5 μM |
| Incubation Time: | 72 hours |
| Result: | The fraction of late apoptotic and necrotic cells increased from 10.9% in controls to 30.4% after 72 h. |
Cell Cytotoxicity Assay
| Cell Line: | C-26 and MDA-MB231 cells |
| Concentration: | 1.25, 2.5, 5, 10, 20, 40 μM |
| Incubation Time: | 48 or 72 hours |
| Result: | Exerted cystostatic/cytotoxic effects against tumor cells. |
Cell Cycle Analysis
| Cell Line: | C-26 cells |
| Concentration: | 2.5, 5 μM |
| Incubation Time: | 48 or 72 hours |
| Result: | Resulted in dose- and time-dependent reduction of cells in G1 phase of the cell cycle. |
Western Blot Analysis
| Cell Line: | C-26 cells |
| Concentration: | 1.25, 2.5, 5, 10, 20, 40 μM |
| Incubation Time: | 48 hours |
| Result: | Leaded to accumulation of cleaved (active) caspase-3. |
Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth.
| Animal Model: | BALB/c mice inoculated with C-26 cells |
| Dosage: | 12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o. |
| Administration: | IP or PO; from day 7 to 19 |
| Result: | Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth. |
安全信息
| WGK Germany | 3 |
|---|---|
| TSCA | Yes |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/16 | 032068 | 三水合原卟啉锌, 96%
Zinc protoporphyrin, 96% | 15442-64-5 | 10mg | 724元 |
| 2024/01/16 | 032068 | 三水合原卟啉锌, 96%
Zinc protoporphyrin, 96% | 15442-64-5 | 50mg | 2048元 |