| Company Name: |
United States Biological
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| Tel: |
800.520.3011 or 781.639.5092 |
| Email: |
chemicals@usbio.net |
| Products Intro: |
Product Name:Mesoridazine
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| | MESORIDAZINE Basic information |
| Product Name: | MESORIDAZINE | | Synonyms: | | | CAS: | | | MF: | C21H26N2OS2 | | MW: | 386.57 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | MESORIDAZINE Chemical Properties |
| Melting point | 126 - 131°C (dec.) | | storage temp. | Hygroscopic, Refrigerator, under inert atmosphere | | solubility | Acetonitrile (Slightly), DMSO (Slightly, Heated), Methanol (Slightly) | | form | Solid | | color | Pale Yellow to Orange | | Stability: | Hygroscopic |
| | MESORIDAZINE Usage And Synthesis |
| Uses | Antipsychotic. | | Uses | Mesoridazine acts analogous to other phenothiazine neuroleptics and is used for schizophrenia, behavioral problems, psychoneurotic displays, and in severe and chronic alcoholism. | | Brand name | Lidanar (Novartis). | | Synthesis | Mesoridazine, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylsufinyl)phenothiazine (6.1.13), is synthesized by an analogous scheme, however, it is also synthesized
by alkylating the acidic form of 2-methylthiphenothiazine—methylsulfonylphenothiazine —
using 2-(2-chlorethyl)-1-methylpiperidine.
In order to do this, 2-methylthiophenothiazine is initially acylated at the nitrogen atom
using acetic anhydride, giving 10-acetyl-2-methylthiophenothiazine (6.1.10). The resulting acetyl derivative is further oxidized by hydrogen peroxide into 10-acetyl-2-methylsulfonylpenothiazine (6.1.11). Deacylation of this product in potassium carbonate methanol
solution gives 2-methylsulfonylphenothiazine (6.1.12), which is alkylated by 2-(2-chlorethyl)-1-methylpiperidine in the presence of sodium amide, affording the desired mesoridazine (6.1.13) [31].
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| | MESORIDAZINE Preparation Products And Raw materials |
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