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5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chlo

5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride Suppliers list
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Products Intro: Product Name:5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
CAS:138982-67-9
Purity:99% Package:100g,500g,1kg,5kg,10kg
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Purity:99% Package:500G;1KG;5KG;25KG
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Products Intro: Product Name:5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
CAS:138982-67-9
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Company Name: Hubei Jusheng Technology Co.,Ltd.
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Products Intro: Product Name:ziprasidone hydrochloride hydrate
CAS:138982-67-9
Purity:99% Package:5KG;1KG Remarks:C21H24Cl2N4O2S

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5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride Basic information
Product Name:5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
Synonyms:Ziprasidone (hydrochloride hydrate);5-(2-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one hydrochloride hyd;Ziprasidone for system suitability 2;Ziprasidone for system suitability 1;ZIPRASIDONE HCL;ZIPRASIDONE HYDROCHLORIDE;5-[2-[4-(1,2-benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one hydrochloride;ZIPRASITONE HCl MONOHYDRATE
CAS:138982-67-9
MF:C21H24Cl2N4O2S
MW:467.41186
EINECS:
Product Categories:Other APIs;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles;Pfizer compounds;Sulfur & Selenium Compounds
Mol File:138982-67-9.mol
5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride Structure
5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride Chemical Properties
Melting point 300°C
storage temp. Room temp
solubility DMSO: >10mg/mL
form solid
Merck 14,10171
CAS DataBase Reference138982-67-9(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 3
RTECS NM3241200
HS Code 38220010
MSDS Information
5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride Usage And Synthesis
Chemical PropertiesPale Tan Powder
UsesCombined serotonin (5HT2) and dopamine (D2) receptor antagonist. Used as an antipsychotic.
Usesantipsychotic;Dopamine D2/serotonin 5-HT2 antagonist
DefinitionChEBI: The hydrochloride hydrate salt of ziprasidone.
UsesZiprasidone is the hydrochloride salt of a benzisothiazolylpiperazine analog structurally related to the atypical antipsychotic drug tiospirone that antagonizes both central serotonin 5-HT2A (Ki = 0.42 nM) and dopamine D2 (Ki = 4.8 nM) receptors. It is also a potent agonist at 5-HT1A receptors (Ki = 3.4 nM), increasing cortical dopamine release which may offset negative effects associated with dopamine D2 antagonism, and an inverse agonist at 5-HT1B and 5-HT1D receptors (pKis = 8.8 and 8.6, respectively).[Cayman Chemical]
Brand nameGeodon (Pfizer).
Biological ActivityAtypical antipsychotic that displays combined serotonin and dopamine receptor antagonism. Displays high affinity at 5-HT 2A receptors with a 5-HT 2A /D 2 affinity ratio greater than any other clinically available atypical antipsychotics (pK i values are 9.38, 8.88, 8.69, 8.47, 8.32, 8.14, 7.98, 7.49, 7.33 and 6.28 for 5-HT 2A , 5-HT 2C , 5-HT 1D , 5-HT 1A , D 2 , D 3 , α 1 , D 4 , H 1 and D 1 receptors respectively).
5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride Preparation Products And Raw materials
Raw materialsIsopropanol-->1,4-Diazacyclohexane-->Indole-->Serotonin hydrochloride
Tag:5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride(138982-67-9) Related Product Information
3-(1-Piperazinyl)-1,2-benzisothiazole Ziprasidone mesilate Ziprasidone Thiazole 4-[2-(4-methylpiperazin-1-yl)ethyl]aniline 1-(2-PHENYLETHYL)PIPERAZINE 1,2-Benzisothiazol-3-amine N-[4-(2-aminoethyl)phenyl]acetamide 4-(2-DIMETHYLAMINO-ETHYL)-ANILINE DIHYDROCHLORIDE 3-Piperazinobenzisothiazole hydrochloride 5-[2-[4-(1,2-Benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride 6-Chloro-5-methylindoline etisazole 6-CHLORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE 1,2-BENZISOTHIAZOLE 6-Chlorooxindole 1H-INDOLE,5-ETHYL-2,3-DIHYDRO- 6-CHLORO-2,3-DIHYDRO-1H-INDOLE