- amoxicillin
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- $0.00 / 25KG
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2023-09-08
- CAS:1066-17-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- COLISTIN
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- $0.80 / 1kg
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2023-04-12
- CAS:1066-17-7
- Min. Order: 1kg
- Purity: 99.95%HTCL
- Supply Ability: 10Tons
- amoxicillin
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- $1.00 / 1PCS
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2021-01-19
- CAS:1066-17-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| Product Name: | COLISTIN | | Synonyms: | COLISTIN;colimycin;1264-72-8 (Sulfate);Aids033059;Aids-033059;Colistin, ColiMycin M, BelcoMycin, ColyMycin, Torazin;PolyMyxin E coMplex;Polyoxin W.P. | | CAS: | 1066-17-7 | | MF: | C52H98N16O13 | | MW: | 1155.43 | | EINECS: | 213-907-3 | | Product Categories: | | | Mol File: | 1066-17-7.mol |  |
| | COLISTIN Chemical Properties |
| Boiling point | 807.67°C (rough estimate) | | density | 1.1050 (rough estimate) | | refractive index | 1.6700 (estimate) | | storage temp. | Store at -20°C | | solubility | PBS (pH 7.2): 10 mg/ml | | CAS DataBase Reference | 1066-17-7 |
| RIDADR | 3249 | | HazardClass | 6.1(b) | | PackingGroup | III | | Hazardous Substances Data | 1066-17-7(Hazardous Substances Data) | | Toxicity | cat,LDLo,subcutaneous,250mg/kg (250mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Antibiotiki. Vol. 5(4), Pg. 10, 1960. |
| | COLISTIN Usage And Synthesis |
| Neurotoxicity and Nephrotoxicity | Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.
| | Uses | Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect. | | Brand name | Coly-Mycin (Monarch). |
| | COLISTIN Preparation Products And Raw materials |
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