- N-BUTYLIDENEPHTHALIDE
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- $5.00 / 1kg
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2024-08-17
- CAS:551-08-6
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 100000
- N-BUTYLIDENEPHTHALIDE
-
- $50.00 / 1kg
-
2024-04-27
- CAS:551-08-6
- Min. Order: 1kg
- Purity: 99.10%
- Supply Ability: 50000kg
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| N-BUTYLIDENEPHTHALIDE Chemical Properties |
Melting point | 82.5°C | Boiling point | 139-142 °C/5 mmHg (lit.) | density | 1.103 g/mL at 25 °C (lit.) | FEMA | 3333 | 3-BUTYLIDENEPHTHALIDE | refractive index | n20/D 1.577(lit.) | Fp | >230 °F | storage temp. | Refrigerator | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) | form | Oil | color | Colourless to Yellow | Odor | at 10.00 % in dipropylene glycol. herbal lovage celery | Odor Type | herbal | JECFA Number | 1170 | BRN | 5145 | InChIKey | WMBOCUXXNSOQHM-FLIBITNWSA-N | LogP | 3.72 | CAS DataBase Reference | 551-08-6(CAS DataBase Reference) | EPA Substance Registry System | 1(3H)-Isobenzofuranone, 3-butylidene- (551-08-6) |
Hazard Codes | Xn | Risk Statements | 22 | Safety Statements | 23 | WGK Germany | 2 | RTECS | TI3692500 | TSCA | Yes |
| N-BUTYLIDENEPHTHALIDE Usage And Synthesis |
Description | N-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder. It is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort. It has found that it can regulate tumor stem cell genes EZH2/AXL and reduced its migration and invasion in glioblastoma. Moreover, it can induce apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2a and telomerase activity. Therefore, it is a potential cancer chemotherapy drug. Moreover, It can also exhibit protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3. Finally, it has certain antiplatelet effect.
| Reference |
- Lin, Po Cheng, et al. "Orphan nuclear receptor, Nurr‐77 was a possible target gene of butylidenephthalide chemotherapy on glioblastoma multiform brain tumor." Journal of Neurochemistry 106.3(2010):1017-1026.
- Rajamani, K, et al. "n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3." Neuropharmacology 117(2017):434-446.
- Teng, C. M., et al. "Antiplatelet effect of butylidenephthalide." BBA General Subjects 924.3(1987):375-382.
| Chemical Properties | 3-Butylidenephthalide has a pervasive warm spicy aroma. | Occurrence | Reported as occurring naturally in the fruits and roots of Ligusticum acutilobum and lovage (Levisticum officinale)
seeds, roots and leaves. | Uses | 3-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder. | Definition | ChEBI: A gamma-lactone that is phthalide substituted by a butylidene group at position 3. Isolated from Ligusticum porteri, it exhibits hypoglycemic activity. | Taste threshold values | Taste characteristics at 15 ppm: celery, green, vegetable-like with a herbal nuance. | General Description | 3-Butylidenephthalide is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort. | Safety Profile | Moderately toxic by
ingestion. A skin irritant. When heated to
decomposition it emits acrid smoke and
irritating fumes. | target | Nrf2 | TNF-α | NO | IL Receptor |
| N-BUTYLIDENEPHTHALIDE Preparation Products And Raw materials |
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