- 2,4-Dibromothiazole
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- $0.00 / 25kg
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2025-12-01
- CAS:4175-77-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
- 2,4-Dibromothiazole
-
- $1.60 / 100kg
-
2025-10-13
- CAS:4175-77-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
- 2,4-Dibromothiazole
-
- $0.00 / 25KG
-
2025-06-27
- CAS:4175-77-3
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | 2,4-Dibromothiazole Basic information |
| Product Name: | 2,4-Dibromothiazole | | Synonyms: | 2,4-DIBROMOTHIAZOLE;2,4-BROMOTHIAZOLE;2,4-DIBROMOTHIAZOLE 98%;2,4-Dibromothiazole ,98%;2,4-DIBROMOTHIAZOLE, 97+%;2,4-Dibrmothiazole;2,4-dibormothiazole;Thiazole, 2,4-dibroMo- | | CAS: | 4175-77-3 | | MF: | C3HBr2NS | | MW: | 242.92 | | EINECS: | 629-026-6 | | Product Categories: | Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;ThiazolesHeterocyclic Building Blocks;Halogenated;Organohalides;Thiazole;Thiazoles;blocks;Bromides | | Mol File: | 4175-77-3.mol |  |
| | 2,4-Dibromothiazole Chemical Properties |
| Melting point | 80-84 °C | | Boiling point | 242.8±13.0 °C(Predicted) | | density | 2.324±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Methanol[soluble in] | | solubility | soluble in Methanol | | form | powder to crystal | | pka | -1.93±0.10(Predicted) | | color | White to Light yellow | | InChI | InChI=1S/C3HBr2NS/c4-2-1-7-3(5)6-2/h1H | | InChIKey | MKEJZKKVVUZXIS-UHFFFAOYSA-N | | SMILES | S1C=C(Br)N=C1Br | | CAS DataBase Reference | 4175-77-3(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-37/38-41-36/37/38 | | Safety Statements | 26-39-36-37/39 | | WGK Germany | 3 | | Hazard Note | Harmful | | HazardClass | IRRITANT, KEEP COLD | | HS Code | 29349990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 2,4-Dibromothiazole Usage And Synthesis |
| Chemical Properties | Off-white crystalline powder | | Uses | Building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain. | | Uses | 2,4-Dibromothiazole is an intermediate used in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modula
tors. | | Uses | 2,4-Dibromothiazole is applied as a building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain. It is also used as an intermediate in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modulators. | | Synthesis | General procedure for the synthesis of 2,4-dibromothiazoles from 2,4-thiazolidinediones:
Example 41: Preparation of 2-amino-3-methyl-5-(3-pyrimidin-5-ylphenyl)-5-(1,3-thiazol-4-yl)-3,5-dihydro-4H-imidazol-4-one
Step a) Preparation of compound 2
A mixture of 2,4-thiazolidinedione 1 (2.28 g, 19.5 mmol) with phosphorus tribromide (25.0 g, 87.0 mmol) was heated at 130°C for 30 min and subsequently cooled to room temperature. The reaction mixture was diluted with ice water (300 mL) and neutralized by batchwise addition of solid sodium carbonate. After neutralization was complete, the mixture was extracted with dichloromethane (3 x 150 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (silica gel, elution gradient: 0:100 to 5:95 ethyl acetate/hexane) to afford compound 2 (3.34 g, 71%) as light yellow crystals.1H NMR (500 MHz, CDCl3) δ 7.21 (s, 1H). | | References | [1] Journal of Organic Chemistry, 2006, vol. 71, # 10, p. 3754 - 3761
[2] Synthesis, 2012, vol. 44, # 7, p. 1026 - 1029
[3] Journal of Materials Chemistry C, 2017, vol. 5, # 45, p. 11927 - 11936
[4] Patent: US2007/4786, 2007, A1. Location in patent: Page/Page column 21
[5] Tetrahedron, 2006, vol. 62, # 38, p. 9017 - 9037 |
| | 2,4-Dibromothiazole Preparation Products And Raw materials |
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