ChemicalBook > Product Catalog >API >Blood System Drugs >Blood volume expansion agent >Sodium carboxyl methylstarch

Sodium carboxyl methylstarch

Sodium carboxyl methylstarch Suppliers list
Company Name: Neostar United (Changzhou) Industrial Co., Ltd.
Tel: +0086-519-85557386
Email: marketing1@neostarunited.com
Products Intro: Product Name:Sodium Starch Glycolate
CAS:9063-38-1
Package:As requirement
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Sodium Starch Glycolate
CAS:9063-38-1
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:9063-38-1
CAS:9063-38-1
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:Sodium carboxyl methylstarch fandachem
CAS:9063-38-1
Purity:As coa Package:As request Remarks:9063-38-1
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Email: info@tnjchem.com
Products Intro: Product Name:Sodium carboxyl methylstarch
CAS:9063-38-1
Purity:99.9% Package:1KG;5USD

Lastest Price from Sodium carboxyl methylstarch manufacturers

  • Sodium Starch Glycolate
  • US $8.70 / Kg/Bag
  • 2021-08-26
  • CAS:9063-38-1
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 10000kg
Sodium carboxyl methylstarch Basic information
Product Name:Sodium carboxyl methylstarch
Synonyms:sodium carboxyl methylstarch;SODIUM STARCH GLYCOLATE;SODIUM STARCH GLYCOLLATE;PRIMOJEL(R);CARBOXYMETHYL STARCH SODIUM;CARBOXYMETHYL STARCH SODIUM SALT;SodiumStarchGlycolateExtraPure;Primojel
CAS:9063-38-1
MF:C2H4O3·xNa·x
MW:0
EINECS:618-597-7
Product Categories:
Mol File:Mol File
Sodium carboxyl methylstarch Structure
Sodium carboxyl methylstarch Chemical Properties
storage temp. Inert atmosphere,Room Temperature
solubility Practically insoluble in methylene chloride. It gives a translucent suspension in water.
form neat
CAS DataBase Reference9063-38-1
EPA Substance Registry SystemStarch, carboxymethyl ether, sodium salt (9063-38-1)
Safety Information
WGK Germany 1
HS Code 3505100092
MSDS Information
Sodium carboxyl methylstarch Usage And Synthesis
Chemical PropertiesWhite or almost white, fine, free-flowing powder, very hygroscopic.
Chemical PropertiesSodium starch glycolate is a white or almost white free-flowing very hygroscopic powder. The PhEur 6.0 states that when examined under a microscope it is seen to consist of: granules, irregularly shaped, ovoid or pear-shaped, 30–100 mm in size, or rounded, 10–35 mm in size; compound granules consisting of 2–4 components occur occasionally; the granules have an eccentric hilum and clearly visible concentric striations. Between crossed nicol prisms, the granules show a distinct black cross intersecting at the hilum; small crystals are visible at the surface of the granules. The granules show considerable swelling in contact with water.
UsesSodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is recommended to use in tablets prepared by either directcompression or wet-granulation processes.
Production MethodsSodium starch glycolate is a substituted derivative of potato starch. Typically, commercial products are also crosslinked using either sodium trimetaphosphate (Types A and B) or dehydration (Type C).
Starch is carboxymethylated by reacting it with sodium chloroacetate in an alkaline, nonaqueous medium, typically denatured ethanol or methanol, followed by neutralization with citric acid, acetic acid, or some other acid. Vivastar P is manufactured in methanolic medium, and Explotab in ethanolic medium.
Pharmaceutical ApplicationsSodium starch glycolate is widely used in oral pharmaceuticals as a disintegrant in capsule and tablet formulations. It is commonly used in tablets prepared by either direct-compression or wet-granulation processes. The usual concentration employed in a formulation is between 2% and 8%, with the optimum concentration about 4%, although in many cases 2% is sufficient. Disintegration occurs by rapid uptake of water followed by rapid and enormous swelling.
Although the effectiveness of many disintegrants is affected by the presence of hydrophobic excipients such as lubricants, the disintegrant efficiency of sodium starch glycolate is unimpaired. Increasing the tablet compression pressure also appears to have no effect on disintegration time.
Sodium starch glycolate has also been investigated for use as a suspending vehicle.
SafetySodium starch glycolate is widely used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. However, oral ingestion of large quantities may be harmful.
storageTablets prepared with sodium starch glycolate have good storage properties. Sodium starch glycolate is stable although very hygroscopic, and should be stored in a well-closed container in order to protect it from wide variations of humidity and temperature, which may cause caking.
The physical properties of sodium starch glycolate remain unchanged for up to 3 years if it is stored at moderate temperatures and humidity.
IncompatibilitiesSodium starch glycolate is incompatible with ascorbic acid.
Regulatory StatusIncluded in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Sodium carboxyl methylstarch Preparation Products And Raw materials
Raw materialsAcrylonitrile-->Sodium chloroacetate
Tag:Sodium carboxyl methylstarch(9063-38-1) Related Product Information
Sodium N-cyclohexylsulfamate Sodium gluconate 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE PHENYLSELENOL Tosylmethyl isocyanide Tris(2,4-pentanedionato)chroMiuM(III) 2,4-PENTANEDIONE, SILVER DERIVATIVE TERT-BUTYL ISOCYANIDE METHYL ISOCYANOACETATE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Aluminum acetylacetonate COBALT ETHYLENE DIAMINE CHLORIDE Ethyl isocyanoacetate COBALT(II) ACETYLACETONATE N-BUTYLISOCYANIDE sodium Sodium carboxyl methylstarch Carboxymethyl starch