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AZIMILIDE

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Products Intro: Product Name:Azimilide
CAS:149908-53-2
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
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Products Intro: Product Name:AziMilide
CAS:149908-53-2
Purity:Typically NLT 98%
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Products Intro: Product Name:Azimilide
CAS:149908-53-2
Company Name: Shanghai Famo Bio-chemical Technology Company Ltd.  
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Products Intro: Product Name:AziMilide
CAS:149908-53-2
Purity:98%
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Products Intro: Product Name:Azimilide
CAS:149908-53-2
Purity:>98% Package:600RMB/5mg
AZIMILIDE Basic information
Product Name:AZIMILIDE
Synonyms:AZIMILIDE;1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione;Azimilide (NE-10064);NE-10064;2,4-Imidazolidinedione, 1-(((5-(4-chlorophenyl)-2-furanyl)methylene)amino)-3-(4-(4-methyl-1-piperazinyl)butyl)-;Unii-74qu6p2934
CAS:149908-53-2
MF:C23H28ClN5O3
MW:457.95
EINECS:
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Mol File:149908-53-2.mol
AZIMILIDE Structure
AZIMILIDE Chemical Properties
density 1.32
Safety Information
MSDS Information
AZIMILIDE Usage And Synthesis
UsesCardiac depressant (anti-arrhythmic).
General DescriptionAzimilide, E-1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione, is a class III agent that significantlyblocks the delayed rectifier potassium current,Iks, including the Ikr component. Its ability to block multichannelsmay be caused by a lack of the methane sulfonamidegroup that is common to other class III agents, whichselectively block the Ikr potassium current. It is believedthat blocking both Ikr and Iks potassium currents yields consistentclass III antiarrhythmic effects at any heart rate.
Enzyme inhibitorThis class ΙΙΙ antiarrhythmic drug and ion channel blocker (FW = 457.95 g/mol; CAS 149908-53-2), also known by the code name NE-10064 and systematic name, 1- ({ (E) -[5- (4-chlorophenyl) furan-2-yl]methylidene} amino) -3-[4- (4-methylpiperazin-1-yl) butyl]-imidazolidine-2,4-dione, blocks both the slow-activating IKs and rapidly activating IKr components of the delayed rectifier potassium current, distinguishing its action from conventional potassium channel blockers such as sotalol and dofetilide, which block only IKr. Azimilide prolongs the cardiac refractory period in a dose-dependent manner, as manifested by increases in action potential duration, QTc interval, and effective refractory period.
AZIMILIDE Preparation Products And Raw materials
Raw materials1-Methylpiperazine-->1-Chlorobutane-->2-Butyl-3-(3,5-Diiodo-4-hydroxy benzoyl) benzofuran
Tag:AZIMILIDE(149908-53-2) Related Product Information
Dofetilide PILSICAINIDE IBUTILIDE 1-Aminohydantoin hydrochloride 2-FURALDEHYDE DIMETHYLHYDRAZONE 2-Furaldehyde, semicarbazone AZIMILIDE