(2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸
| 中文名称 | (2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 |
|---|---|
| 中文同义词 | (2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸;(ALPHAS)-ALPHA-氨基-ALPHA-[(1S,2S)-2-羧基环丙基]-9H-吨-9-丙酸 |
| 英文名称 | LY 341495 |
| 英文同义词 | LY 341495;(2S)-2-AMINO-2-[(1S,2S)-2-CARBOXYCYCLOPROP-1-YL]-3-(XANTH-9-YL) PROPANOIC ACID;(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid LY 341495;(alphaS)-alpha-Amino-alpha-[(1S,2S)-2-carboxycyclopropyl]-9H-xanthene-9-propanoic acid;CS-416;(1S,2S)-2-[(1S)-1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid;LY 341495;LY-341495;9H-Xanthene-9-propanoic acid, α-amino-α-[(1S,2S)-2-carboxycyclopropyl]-, (αS)- |
| CAS号 | 201943-63-7 |
| 分子式 | C20H19NO5 |
| 分子量 | 353.37 |
| EINECS号 | |
| 相关类别 | G蛋白偶联受体&G蛋白;Glutamate |
| Mol文件 | 201943-63-7.mol |
| 结构式 | ![(2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 结构式](CAS/GIF/201943-63-7.gif) |
(2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 性质
| 沸点 | 580.8±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.432 |
| 储存条件 | Store at RT |
| 溶解度 | 溶解度有限，溶于DMSO |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 2.02±0.10(Predicted) |
|
mGluR1a 7.8 μM (IC 50 ) |
mGluR2 21 nM (IC 50 ) |
mGluR3 14 nM (IC 50 ) |
mGluR4 22 μM (IC 50 ) |
mGluR5a 8.2 μM (IC 50 ) |
mGluR7 990 nM (IC 50 ) |
mGluR8 170 nM (IC 50 ) |
LY341495 (0.3, 1, and 3 mg/kg, i.p.) displays a lower level of discrimination in rats. LY341495 (3.0 mg/kg) decreases Dvl-2, pGSK-3α/β and β-catenin protein levels but Dvl-1, Dvl-3 and GSK-3α/β are unaffected in both the PFC and STR. LY341495 has the generally the opposite effect following acute and chronic administration compared to mGlu2/3 agonist, LY379268. LY341495 (3 mg/kg, i.p., 2.5 h) -induced c-Fos expression is not altered in either KO brain. LY341495 is almost inactive in the central extended amygdala [central nucleus of the amygdala, lateral (CeL) and bed nucleus of the stria terminalis, laterodorsal (BSTLD)] in mGluR3-KO mice.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-70059 | LY341495 | 1 mg | 500元 | |
| 2024/01/25 | HY-70059 | (2S)-2-氨基-2-[(1S,2S)-2-羧基环丙-1-基]-3-(吨-9-基)丙酸 LY341495 | 201943-63-7 | 5mg | 1100元 |