| Company Name: |
Merck Millipore |
| Tel: |
1-400-889-1988 400-889-1988 |
| Email: |
bioscience@merckgroup.com |
| Company Name: |
Merck KGaA |
| Tel: |
21-20338288 |
| Email: |
ordercn@merckgroup.com |
| Company Name: |
SIGMA-RBI |
| Tel: |
800 736 3690 (Orders) |
| Email: |
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| | C5-DEPLETED SERUM, HUMAN Basic information |
| | C5-DEPLETED SERUM, HUMAN Chemical Properties |
| storage temp. | -70°C | | form | solution | | biological source | human |
| Hazard Codes | B | | WGK Germany | 3 | | Storage Class | 12 - Non Combustible Liquids |
| | C5-DEPLETED SERUM, HUMAN Usage And Synthesis |
| Uses | Complement C5 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp. (such as meningitis). Deficiency in C5 results in an impairment of hemolytic activity from both the classical and alternative pathway of the complement system. Recently, genetic research has revealed that a 153 bp deletion in exon 30 results in complete C5 deficiency. Research has also implicated C5 deficiency in a predisposition to cardiac dysfunction when cardiac injury occurs. | | Biochem/physiol Actions | Complement C5 deficiency can, paradoxically, protect against certain effects of infection. Patients deficient in C5 are unusually susceptible to meningococcal infection, but have a milder course of infection. Reduced expression of tumor necrosis factor (TNF) may account for this effect. |
| | C5-DEPLETED SERUM, HUMAN Preparation Products And Raw materials |
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