| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Am404
CAS:198022-70-7
Package:10mg, 50mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:AM 404;N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenaMide
CAS:198022-70-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Ascent Scientific
|
| Tel: |
4401179829988 |
| Email: |
customerservice@ascentscientific.co.uk |
| Products Intro: |
Product Name:AM404
CAS:198022-70-7
Purity:>99% Package:10mg;50mg Remarks:Anandamide transport inhibitor
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| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:AM 404
CAS:198022-70-7
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:AM 404
CAS:198022-70-7
Purity:98% Package:10mg; 50mg Remarks:Medbio
|
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| Product Name: | AM 404 | | Synonyms: | N-(4-HYDROXYPHENYL)ARACHIDONYLAMIDE \ AN;N-(4-HYDROXYPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;N-(4-HYDROXYPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRENAMIDE;N-(4-HYDROXYPHENYL)-ARACHIDONAMIDE;N-(4-HYDROXYPHENYL) ARACHIDONOYLAMIDE;N-(4-HYDROXYPHENYL)ARACHIDONYLAMIDE;ARACHIDONOYLAMIDE, N-(4-HYDROXYPHENYL);AM 404 | | CAS: | 198022-70-7 | | MF: | C26H37NO2 | | MW: | 395.58 | | EINECS: | | | Product Categories: | Cannabinoid receptor;Cannabinoid | | Mol File: | 198022-70-7.mol |  |
| | AM 404 Chemical Properties |
| storage temp. | −20°C | | solubility | ethanol: 24 mg/mL Photosensitive solution. | | form | solution | | color | White | | Sensitive | Air Sensitive | | Stability: | Stable for 1 year from date of purchase as supplied. Compound is subject to oxidation, store under inert gas to protect from exposure to air. Solutions in DMSO or ethanol may be stored under nitrogen or argon at -20° for up to 3 months. |
| | AM 404 Usage And Synthesis |
| Description | AM-404 (198022-70-7) inhibits anandamide transport (IC50?= 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2?Vanilloid receptors are activated by AM-404.3?Active?in vivo.1 | | Biological Activity | Competitive and selective inhibitor of carrier-mediated anandamide transport (IC 50 = 1 μ M). Does not activate CB 1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC 50 = 7.4). Active in vivo . Also available in water soluble emulsion (N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ). | | References | 1) Calignano?et al. (1997),?Potentiation of anandamide hypotension by the transport inhibitor AM404; Eur. J. Pharmacol.,?337?R1
2) Beltramo?et al. (1997), Functional role of high-affinity anandamide transport, as revealed by selective inhibition; Science,?277?1094
3) Zygmunt?et al. (2000),?The anandamide inhibitor AM404 activates vanilloid receptors: Eur. J. Pharmacol.?396?39 |
| | AM 404 Preparation Products And Raw materials |
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