| Company Name: |
amyjet |
| Tel: |
4006800868;027-59626688 18771149750 |
| Email: |
sales@amyjet.com |
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| Product Name: | DAPT | | Synonyms: | (3,5-DIFLUOROPHENYLACETYL)-ALA-PHG-OTBU;(3,5-DIFLUOROPHENYLACETYL)-ALA-PHG-OBUT;(3,5-DIFLUOROPHENYLACETYL)-L-ALANYL-L-2-PHENYLGLYCINE T-BUTYL ESTER;(3,5-DIFLUOROPHENYLACETYL)-L-ALANYL-PHENYLGLYCINE T-BUTYL ESTER;GAMMA-SECRETASE INHIBITOR IX;LY-374973;N-[N-(3,5-DIFLUOROPHENACETYL-L-ALANYL)]-S-PHENYLGLYCINE T-BUTYL ESTER | | CAS: | | | MF: | C23H26F2N2O4 | | MW: | 432.46 | | EINECS: | | | Product Categories: | peptides | | Mol File: | Mol File |  |
| Melting point | 137 - 144°C | | storage temp. | 2-8°C | | solubility | DMSO: ~18 mg/mL | | form | solid | | color | white |
| Uses | DAPT is a γ-secretase inhibitor which inhibits thegrowth of cancer cells and epethelial and mesenchymal transition (1,2). | | Background | DAPT is a potent γ-secretase inhibitor. Research studies have demonstrated that DAPT inhibits production of total β-amyloid peptide and Aβ42 in human primary neuronal cultures with an IC50 of 115 nM and 200 nM, respectively. DAPT-induced inhibition of Notch1 signaling prevents cleavage formation of the Notch1 intracellular domain, resulting in down regulation of target gene transcription. DAPT treatment has been shown to induce apoptosis in Jurkat and lung squamous cell carcinoma cell lines. | | References | [1] Dovey, H.F. et al. (2001) J Neurochem 76, 173-81.
[2] Luo, X. et al. (2013) Cancer Cell Int 13, 34.
[3] Cao, H. et al. (2012) APMIS 120, 441-50. |
| | DAPT Preparation Products And Raw materials |
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