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| | (S)-N-Fmoc-2-(2'-propylenyl)alanine Basic information |
| Product Name: | (S)-N-Fmoc-2-(2'-propylenyl)alanine | | Synonyms: | (S)-N-Fmoc-2-(2'-propylenyl)alanine;(2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-4-pentenoic acid;(S)-N-Fmoc-alpha-allylalanine;(S)-N-(9-Fluorenylmethylcarbamate)-2-(2'-propylenyl)alanine;Fmoc-alpha-methyl-L-allylglycine;(S)-N-FMOC-Α-ALLYLALANINE;FMoc-α-Me-Gly(Allyl)-OH;(S)-N-Fmoc-α-2-n-propenylalanine | | CAS: | 288617-71-0 | | MF: | C21H21NO4 | | MW: | 351.4 | | EINECS: | | | Product Categories: | α-Methyl Amino Acids | | Mol File: | 288617-71-0.mol |  |
| | (S)-N-Fmoc-2-(2'-propylenyl)alanine Chemical Properties |
| Boiling point | 564.3±45.0 °C(Predicted) | | density | 1.224 | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | pka | 3.81±0.11(Predicted) | | form | liquid | | color | pale yellow | | InChIKey | FNCSRFHDUZYOCR-NRFANRHFSA-N |
| Hazard Codes | N | | Risk Statements | 50 | | Safety Statements | 61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | TSCA | No |
| | (S)-N-Fmoc-2-(2'-propylenyl)alanine Usage And Synthesis |
| Uses | Olefinic alpha-methyl amino acid for peptide stapling. Upon incorporation of this amino acid into a peptide, along with another of the same or derivative with a different length of the olefinic side chain, the two can be ′stapled′ via a ring closing metathesis reaction with Grubb′s catalyst (product # 579726). The resulting stapled peptide macrocycle has been shown to stabilize the alpha-helical structure of peptides, which can lead to favorable biological characteristics such as increased proteolytic stability and cellular uptake. |
| | (S)-N-Fmoc-2-(2'-propylenyl)alanine Preparation Products And Raw materials |
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