(+)-Fluprostenol

(+)-Fluprostenol Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:[3H]-Travoprost acid
CAS:54276-17-4
Purity:0.99 Package:5KG;1KG Remarks:C23H29F3O6
Company Name: Standardpharm Co. Ltd.
Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Products Intro: Product Name:Travoprost Impurity 12(Fluprostenol)
CAS:54276-17-4
Purity:0.99 Package:10mg;25mg;50mg;100mg
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:Travoprost Acid
CAS:54276-17-4
Package:10mg Remarks:BOC Sciences also provides custom synthesis services for Travoprost Acid.
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-29-87569266 15319487004
Email: 1015@dideu.com
Products Intro: Product Name:(+)-Fluprostenol
CAS:54276-17-4
Purity:99.0% Package:100g;1kg;5kg;25kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:(+)-Fluprostenol;AL-5848;Fluprostenol, (+)-;Travoprost acid
CAS:54276-17-4
Package:1 mg;1 mL * 10mM (in DMSO);10 mg;100 mg;200 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
(+)-Fluprostenol Basic information
Product Name:(+)-Fluprostenol
Synonyms:[1R-[1α(Z),2β(1E,3R*),3α,5α]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoroMethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid;16-(M-TrifluoroMethylphenoxy)-17,18,19,20-tetranorprostaglandin F2α;AL 5848;Travoprost Acid;Ttravoprost free acid;Travoprost Acid-d4;[3H]-Travoprost acid;Travoprost Impurity 12(Fluprostenol)
CAS:54276-17-4
MF:C23H29F3O6
MW:458.47
EINECS:
Product Categories:Agonists;Chiral Reagents;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;API
Mol File:54276-17-4.mol
(+)-Fluprostenol Structure
(+)-Fluprostenol Chemical Properties
Boiling point 608.0±55.0 °C(Predicted)
density 1.335±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly, Sonicated), Dichloromethane, Acetonitrile
form Solid
pka4.76±0.10(Predicted)
color Colourless to Pale Yellow Oil
Safety Information
HS Code 2937500000
MSDS Information
(+)-Fluprostenol Usage And Synthesis
UsesFluprostenol is a metabolically stable analog of PGF2α with potent FP receptor agonist activity. Fluprostenol is the optically active enantiomer of fluprostenol and would be expected to have twice the potency as the racemic mixture. Fluprostenol inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively. It is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 μg/kg to terminate pregnancy. It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3-10 x 10?11 M.[Cayman Chemical]
UsesA metabolically stable analog of Prostaglandin F2α (P838625) with potent FP receptor agonist activity. An impurity of Travoprost (T715600).
DefinitionChEBI: Fluprostenol is an organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea. It has a role as an antiglaucoma drug, an antihypertensive agent, a prostaglandin receptor agonist, a female contraceptive drug and an abortifacient. It is a prostaglandins Falpha, a hydroxy monocarboxylic acid and a member of (trifluoromethyl)benzenes.
Tag:(+)-Fluprostenol(54276-17-4) Related Product Information
Tafluprost Iodoethane Ethyl bromoacetate 15(S)-Fluprostenol isopropyl ester Travoprost 15-KETO FLUPROSTENOL 5,6-trans Travoprost 3-Trifluoromethylphenol 15-Keto Travoprost 9-keto Fluprostenol isopropyl ester 9-KETO FLUPROSTENOL (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide 11-KETO FLUPROSTENOL