- 3-Indazolamine
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- $0.00 / 1KG
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2022-01-04
- CAS:874-05-5
- Min. Order: 1g
- Purity: 98%minHPLC
- Supply Ability: 100kg/month
- 1H-INDAZOL-3-YLAMINE
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- $15.00 / 1KG
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2021-08-12
- CAS:874-05-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 1H-INDAZOL-3-YLAMINE
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- $1.00 / 1KG
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2019-07-06
- CAS:874-05-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: Customized
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| | 1H-INDAZOL-3-YLAMINE Basic information | | Uses |
| | 1H-INDAZOL-3-YLAMINE Chemical Properties |
| Melting point | 156-157°C | | Boiling point | 376.6±15.0 °C(Predicted) | | density | 1.367±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 14.89±0.40(Predicted) | | form | Liquid or Solid | | color | Clear, colorless or white to pale yellow | | InChI | InChI=1S/C7H7N3/c8-7-5-3-1-2-4-6(5)9-10-7/h1-4H,(H3,8,9,10) | | InChIKey | YDTDKKULPWTHRV-UHFFFAOYSA-N | | SMILES | N1C2=C(C=CC=C2)C(N)=N1 | | CAS DataBase Reference | 874-05-5(CAS DataBase Reference) | | EPA Substance Registry System | 1H-Indazol-3-amine (874-05-5) |
| | 1H-INDAZOL-3-YLAMINE Usage And Synthesis |
| Uses | 1H-Indazol-3-amine is a reagent used in the preparation of indazole derivatives as potential antimicrobial and antitumor agents. | | Chemical Properties | Light yellow crystals | | Uses | 1H-Indazol-3-amine is a reagent used in the preparation of indazole derivatives as potential antimicrobial and antitumor agents. | | Definition | ChEBI: 1H-indazol-3-amine is a member of indazoles. | | Synthesis | Example 21.1: Preparation of methyl 3-hydroxy-4-oxo-4,6-dihydro-pyrimido[1,2-b]indazole-2-carboxylate
Step 1: 2-Fluorobenzonitrile (605 mg, 5 mmol) was mixed with 85% hydrazine hydrate (352 mg, 6 mmol) in 1-butanol (3 mL). The reaction mixture was heated to reflux and stirred for 5 hours. After completion of the reaction, it was cooled to room temperature and the precipitate was collected by filtration. The filter cake was washed with dichloromethane and subsequently dried under vacuum to give 3-aminoindazole (293 mg, 44% yield).
1H NMR (300 MHz, D6-DMSO): δ 5.26-6.36 (brs, 2H), 6.84-6.93 (m, 1H), 7.18-7.24 (m, 2H), 7.67 (dt, J = 8.1, 0.9 Hz, 1H), 11.33 (s, 1H). | | References | [1] Chemical Communications, 2014, vol. 50, # 85, p. 12911 - 12914
[2] Advanced Synthesis and Catalysis, 2016, vol. 358, # 13, p. 2126 - 2133
[3] Patent: WO2008/77188, 2008, A1. Location in patent: Page/Page column 127-128
[4] Organic Process Research and Development, 2011, vol. 15, # 3, p. 565 - 569
[5] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 23, p. 5293 - 5297 |
| | 1H-INDAZOL-3-YLAMINE Preparation Products And Raw materials |
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