- MC-Val-Cit-PAB-OH
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- $0.00 / 1g
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2024-03-29
- CAS:159857-80-4
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | MC-Val-Cit-PAB Basic information |
| Product Name: | MC-Val-Cit-PAB | | Synonyms: | L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-(hydroxyMethyl)phenyl]-;ML-Val-Cit-PAB;MC-Val-Cit-PAB, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-;MC-Val-Cit-PAB;MC-Val-it-PAB;N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide;EOS-60616;N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymeth | | CAS: | 159857-80-4 | | MF: | C28H40N6O7 | | MW: | 572.65 | | EINECS: | | | Product Categories: | ADCs;ADC Linker;ADC-Linker;ADC-Linkers | | Mol File: | 159857-80-4.mol |  |
| | MC-Val-Cit-PAB Chemical Properties |
| Boiling point | 931.6±65.0 °C(Predicted) | | density | 1.276 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO: soluble | | form | powder to crystal | | pka | 13.41±0.70(Predicted) | | color | White to Almost white | | InChIKey | UMDCMQHPXQLHGR-OFVILXPXSA-N | | SMILES | C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(CO)C=C1 | | CAS DataBase Reference | 159857-80-4 |
| | MC-Val-Cit-PAB Usage And Synthesis |
| Description | MC-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit was designed to be cleaved specifically by Cathepsin B. MC group is reactive with thiol moiety | | Uses | N-[6-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide is used as a reagent to prepare antibody-drug conjugates, which are compounds that selectively deliver cytotoxic drugs to a tumour-associated antigen. |
| | MC-Val-Cit-PAB Preparation Products And Raw materials |
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