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SMIFH2

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SMIFH2 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:SMIFH2
CAS:340316-62-3
Package:10 mg；100 mg；2 mg；200 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:SMIFH2 Formin FH2 Domain Inhibitor
CAS:340316-62-3
Purity:98% Package:$78.9/5mg;$117.9/10mg;$265.9/25mg;$513.9/50mg;$880.9/100mg;Bulk package Remarks:98%
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Products Intro: Product Name:SMIFH2
CAS:340316-62-3
Purity:98% Package:1g;10g;100g
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:SMIFH2
CAS:340316-62-3
Purity:>=98% (HPLC) Package:5MG Remarks:S4826-5MG
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com
Products Intro: Product Name:SMIFH2
CAS:340316-62-3
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
SMIFH2 Basic information
Product Name:SMIFH2
Synonyms:SMIFH2;1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione;Formin FH2 Domain Inhibitor, SMIFH2;Formin FH2 Domain Inhibitor, SMIFH2 - CAS 340316-62-3 - Calbiochem;(5E)-1-(3-bromophenyl)-5-(furan-2-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;5-Furylidene,1-(3-Bromophenyl)-2-Thiobarbituric Acid;SMIFH2 >=98% (HPLC);1-(3-Bromophenyl)-5-(furan-2-ylmethylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS:340316-62-3
MF:C15H9BrN2O3S
MW:377.21
EINECS:
Product Categories:
Mol File:340316-62-3.mol
SMIFH2 Structure
SMIFH2 Chemical Properties
density 1.75±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble20mg/mL, clear
pka5.45±0.20(Predicted)
form powder
color light yellow to yellow-green
Stability:Light Sensitive
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
WGK Germany 3
MSDS Information
SMIFH2 Usage And Synthesis
UsesSMIFH2 was used to decipher the role of mDia2 in controlling microtubule dynamics and myofibroblast differentiation.1
General DescriptionA cell-permeable thiooxodihydropyrimidinedione compound that inhibits both formin-mediated, profilin-independent actin nucleation (IC50 ~15 μM using mDia1 or mDia2) and formin-mediated elongation of actin filaments in the presence of profilin (IC50 ~4 μM using Cdc12 or mDia2), but not the Arp2/3-mediated or formin-independent actin assembly. SMIFH2 targets the FH2 (formin homology 2) domain of formins from a large variety of species, including murine mDia1/2, C. elegans CYK-1, S. pombe Cdc12, S. pombe Fus1, and S. cerevisiae Bni1, and decreases formin affinity for the actin filament barbed end. SMIFH2, at 25 μM, is shown to selectively disrupt formin-dependent actin cables and contractile rings, but not Arp2/3-dependent, CK-666- (Cat. No. 182515) sensitive actin patches, in fission yeast. SMIFH2 is also demonstrated to affect F-actin cytoskeleton structures and cell migration (by a 2-fold decrease at 10 μM) in NIH 3T3 fibroblast cultures.
Biochem/physiol ActionsSMIFH2 is an inhibitor of formin homology 2 domains. The compound is a first small molecule inhibitor of formin-mediated actin assembly that disrupts formin dependent processes from yeast to mammals. SMIFH2 may be a useful drug for identifying cellular processes dependent on formin-mediated actin assembly in a broad range of experimental systems. Formin is an actin nucleation factor.
storageStore at +4°C
SMIFH2 Preparation Products And Raw materials
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