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N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE

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Products Intro: Product Name:Ro 41-1049 hydrochloride
CAS:127917-66-2
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
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Products Intro: Product Name:Ro 41-1049 hydrochloride
CAS:127917-66-2
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Products Intro: Product Name:RO-41-1049 hydrochloride
CAS:127917-66-2
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Products Intro: Product Name:Ro 41-1049 hydrochloride
CAS:127917-66-2
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Products Intro: Product Name:Ro 41-1049 hydrochloride
CAS:127917-66-2
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N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE manufacturers
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Basic information
Product Name:N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
Synonyms:RO 41-1049 HYDROCHLORIDE;N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE;Ro 411049 hydrochloride,Ro 41 1049 hydrochloride;N-(2-Aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide hydrochloride
CAS:127917-66-2
MF:C12H13ClFN3OS
MW:301.76
EINECS:
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Mol File:Mol File
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Structure
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Chemical Properties
storage temp. Store at -20°C
solubility H2O: soluble
form solid
color white
Safety Information
WGK Germany 3
MSDS Information
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SigmaAldrich English
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Usage And Synthesis
UsesRo 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (MAO-A). An homogeneous population of high affinity binding sites for [3H]Ro 41-1049 is found in membrane preparations from human frontal cortex and placenta (Kd values of 16.5 and 64.4 nM, respectively)[1].
in vivo

Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion. Pretreatment with Ro 41-1049 (20 mg/kg) significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing formation of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[2].

Animal Model:Sprague-Dawley rats (200-240 g)[2]
Dosage:1 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, or 50 mg/kg
Administration: Intraperitoneal injection; for 3 hours
Result:Inhibited dopamine metabolite formation and increased dopamine levels in a dose-dependent fashion. Pretreatment with the concentration of 20 mg/kg significantly increased dopamine formation following L-dopa administration while decreasing formation of DOPAC and HVA.
References[1] Cesura AM, et al. Characterization of the binding of [3H]Ro 41-1049 to the active site of human monoamine oxidase-A. Mol Pharmacol. 1990 Mar;37(3):358-66. PMID:2314388
[2] Brannan T, et al. Effect of a selective MAO-A inhibitor (Ro 41-1049) on striatal L-dopa and dopamine metabolism: an in vivo study. J Neural Transm Park Dis Dement Sect. 1994;8(1-2):99-105. DOI:10.1007/BF02250920
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Preparation Products And Raw materials
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