| Company Name: |
Shanghai EFE Biological Technology Co., Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
info@efebio.com |
| Products Intro: |
Product Name:15-Lipoxygenase Inhibitor 1 Exclusive
CAS:928853-86-5
Purity:95% Package:500μg;1mg;5mg
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| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:4-MMPB
CAS:928853-86-5
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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| | 15-Lipoxygenase Inhibitor 1 Basic information |
| Product Name: | 15-Lipoxygenase Inhibitor 1 | | Synonyms: | 15-Lipoxygenase Inhibitor 1;15-Lipoxygenase Inhibitor I;15-Lipoxygenase Inhibitor 1 Exclusive;4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine;15-Lipoxygenase Inhibitor 1(4-MMPB);4-MMPB;15-Lipoxygenast Inhibitorl;LOX,4 MMPB,radical,Inhibitor,inhibit,4-MMPB,scavenging,Lipoxygenase,cancer,Apoptosis,4MMPB,inhibition | | CAS: | 928853-86-5 | | MF: | C16H19N5S | | MW: | 313.42 | | EINECS: | | | Product Categories: | | | Mol File: | 928853-86-5.mol |  |
| | 15-Lipoxygenase Inhibitor 1 Chemical Properties |
| Boiling point | 532.1±60.0 °C(Predicted) | | density | 1.265±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Chloroform: >5mg/ml | | form | A crystalline solid | | pka | 7.17±0.42(Predicted) |
| | 15-Lipoxygenase Inhibitor 1 Usage And Synthesis |
| Biological Activity | 4-MMPB is a selective lipoxygenase 15-lipoxygenase inhibitor with IC50 value of 18 μM. The IC50 values of it against soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1) were 19.5 μM and 19.1 μM, respectively. It has potential for prostate cancer research. | | in vitro | 4-MMPB has an IC 50 of 69.6 μM for DPPH bleaching.
4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.
4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.
Cell Viability Assay | Cell Line: | DU145 cells, PC-3 cells, HFF3 cells | | Concentration: | 9.57 μM, 19.94 μM, 39.88 μM, 79.77 μM, 159.53 μM | | Incubation Time: | 24 hours, 48 hours, 72 hours | | Result: | IC 50 s of 79.76 μM (24 hours), 51.05 μM (48 hours) and 41.48 μM (72 hours) for PC-3 cells, and 255.25 μM (24 hours), 130.81 μM (48 hours) and 98.91 μM (72 hours) for HFF3 cells. | | | target | IC50: 18 μM (15-lipoxygenase) |
| | 15-Lipoxygenase Inhibitor 1 Preparation Products And Raw materials |
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