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Sofosbuvir

Sofosbuvir Suppliers list
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Email: wgp@nanjing-pharmaceutical.com
Products Intro: Product Name:GS-7977
CAS:1190307-88-0
Purity:99% Package:1000KG;;100KG;10KG;5KG;1KG
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Sofosbuvir
CAS:1190307-88-0
Purity:99% Package:1KG;1046USD
Company Name: Frapp's ChemicalNFTZ Co., Ltd.
Tel: +86 (576) 8169-6106
Email: sales@frappschem.com
Products Intro: Product Name:Sofosbuvir
CAS:1190307-88-0
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:Sofosbuvir
CAS:1190307-88-0
Purity:99%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: inquiry@dakenchem.com
Products Intro: Product Name:Sofosbuvir
CAS:1190307-88-0
Purity:99% Package:100g,500g,1KG,10KG,100KG

Lastest Price from Sofosbuvir manufacturers

  • Sofosbuvir
  • US $1046.00 / KG
  • 2018-07-25
  • CAS:1190307-88-0
  • Min. Order: 10G
  • Purity: 99%
  • Supply Ability: 20ton
Sofosbuvir Basic information
Indications and Usage Mechanisms of Action
Product Name:Sofosbuvir
Synonyms:Sofosbuvir (PSI-7977, GS-7977);Sofosbuvir N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate;Suofeibuwei;Sofosbuvir, >=98%;Sofosbubir;Sofosbuvir,GS-7977;(S)-Isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-h
CAS:1190307-88-0
MF:C22H29FN3O9P
MW:529.4525242
EINECS:11-000-0
Product Categories:API;Inhibitors;Liver Disease Series;PSI7977;Pharmaceutical intermediate
Mol File:1190307-88-0.mol
Sofosbuvir Structure
Sofosbuvir Chemical Properties
density 1.41
Safety Information
MSDS Information
Sofosbuvir Usage And Synthesis
Indications and UsageSofosbuvir is the world’s first oral drug for treating hepatitis C and was one of the most important new drugs to be approved in the U.S.A in 2013. It was developed by the American Gillard Scientific Company. It eliminates the need for traditional injection drug interferon (IFN) when treating genotype-specific hepatitis C.
Sofosbuvir is used to treat chronic hepatitis C virus (HCV) infections. It is the first safe and effective drug that does not require IFN when treating HCV infections. There are a few different types of HCV infections. According to the type of infection, treatment regimens can include sofosbuvir and ribavirin, or sofosbuvir, ribavirin and pegylated interferon α.
Mechanisms of ActionSofosbuvir is a type of nucleotide analogue inhibitor. It prevents hepatitis C virus (HCV) from replicating a crucial type of specific protein.
DescriptionSofosbuvir is a drug used for the treatment of hepatitis C. It is recommended to be used in combination with other drugs (such as velpatasvir) for the first-line treatment for HCV genotypes 1, 2, 3, 4, 5, and 6. It takes effect through acting as a nucleotide analog inhibitor, being capable of specially inhibiting the HCV NS5B (non-structural protein 5B) RNA-dependent RNA polymerase.
UsesPSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the t reatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
DefinitionChEBI: A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.
UsesPSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). PSI-7977 is effective in vitro and in vivo.[Cayman Chemical]
Sofosbuvir Preparation Products And Raw materials
Tag:Sofosbuvir(1190307-88-0) Related Product Information
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