卡普瑞林酒石酸盐
| 中文名称 | 卡普瑞林酒石酸盐 |
|---|---|
| 中文同义词 | 酒石酸卡莫瑞林;卡普瑞林酒石酸盐;卡普瑞林L-酒石酸盐;酒石酸己罗莫林;卡普瑞林酒石酸盐,10 MM DMSO 溶液;L-酒石酸卡普瑞林 |
| 英文名称 | CaproMorelin Tartrate |
| 英文同义词 | CaproMorelin Tartrate;CP 424391-18;Capromorelin tartrate (CP-424,391);N-{2-[(3aS)-3a-benzyl-2-methyl-3-methylidene-2,3,3a,4,6,7-hexahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-1-(benzyloxy)-2-oxoethyl}-2-methylalaninamide 2,3-dihydroxybutanedioate (1:1);CS-2136;CP-424391 tartrate;CP 424391-18; CP-424391 TARTRATE;Inhibitor,Growth hormone secretagogue receptor,GHSR,Capromorelin,inhibit,Capromorelin Tartrate |
| CAS号 | 193273-69-7 |
| 分子式 | C32H41N5O10 |
| 分子量 | 655.71 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 193273-69-7.mol |
| 结构式 |  |
卡普瑞林酒石酸盐 性质
| 熔点 | >150oC (dec.) |
|---|---|
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色至浅黄色至浅橙色 |
| 水溶解性 | H2O: 20mg/mL, clear |
| 稳定性 | 吸湿性 |
| InChIKey | MJGRJCMGMFLOET-GTNBBHPYNA-N |
| SMILES | [C@H](O)(C(=O)O)[C@@H](O)C(=O)O.C(C1C=CC=CC=1)[C@]12C(N(C)N=C1CCN(C(=O)[C@H](NC(=O)C(N)(C)C)COCC1C=CC=CC=1)C2)=O |&1:0,5,17,28,r| |
Capromorelin Tartrate 是一种可口服的，有效的growth hormone secretagogue receptor (GHSR)激动剂，对hGHS-R1a的Ki值为 7 nM。
Ki: 7 nM (hGHS-R1a)
Capromorelin stimulates GH release in rat pituitary cell cultures with EC 50 of 3 nM.
Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED 50 of 0.05 mg/kg iv.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 眼部刺激 类别2 经皮刺激 类别2 特异性靶器官毒性-一次接触，类别3 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-15243 | 卡普瑞林酒石酸盐 Capromorelin Tartrate | 193273-69-7 | 2mg | 400元 |
| 2025/12/22 | HY-15243 | 卡普瑞林酒石酸盐 Capromorelin Tartrate | 193273-69-7 | 5mg | 560元 |