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TriMethyl(broModifluoroMethyl)silane

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Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
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Products Intro: Product Name:TriMethyl(broModifluoroMethyl)silane
CAS:115262-01-6
Purity:99.99% Package:1kg;0.1USD|1kg;0.1USD|1kg;0.1USD
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:[Bromo(difluoro)methyl]trimethylsilane
CAS:115262-01-6
Purity:98% Min. Package:1G;1KG;100KG
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
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Products Intro: Product Name:Trimethyl(bromodifluoromethyl)silane
CAS:115262-01-6
Purity:99% Package:1KG,5KG 10KG
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
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Products Intro: CAS:115262-01-6
Purity:97% Package:g-Kg Remarks:Colorless transparent liquid
Company Name: Accela ChemBio Inc.
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Products Intro: Product Name:(Bromodifluoromethyl)trimethylsilane
CAS:115262-01-6
Purity:>=98% Package:1g;5g;10g;25g;100g;500g;1000g Remarks:SY047583

TriMethyl(broModifluoroMethyl)silane manufacturers
TriMethyl(broModifluoroMethyl)silane Basic information
Product Name:TriMethyl(broModifluoroMethyl)silane
Synonyms:(Bromodifluoromethyl)trimethylsilane 98%;TriMethyl(broModifluoroMethyl)silane;Bromodifluoro(trimethylsilyl)methane;(Bromodifluoromethyl);Trimethyl(bromodifluoromethyl)silane 97%;(Bromodifluoromethyl)trimethylsilane >;Silane, (bromodifluoromethyl)trimethyl-;Difluorobromomethylsilane
CAS:115262-01-6
MF:C4H9BrF2Si
MW:203.1
EINECS:806-938-4
Product Categories:
Mol File:115262-01-6.mol
TriMethyl(broModifluoroMethyl)silane Structure
TriMethyl(broModifluoroMethyl)silane Chemical Properties
Boiling point 108°C(lit.)
density 1.306
refractive index n/D1.407
Fp 46℃
storage temp. -20°C
form liquid
color clear
InChIKeyWDZVWBWAUSUTTO-UHFFFAOYSA-N
CAS DataBase Reference115262-01-6
Safety Information
Risk Statements 11
Safety Statements 24/25
RIDADR UN 1993C 3 / PGIII
TSCA No
HazardClass 3
PackingGroup II
HS Code 29319090
MSDS Information
TriMethyl(broModifluoroMethyl)silane Usage And Synthesis
Chemical PropertiesColorless transparent liquid, initial boiling point 108℃, relative density 1.31 g/cm3.
UsesNovel difluorocarbene source for the efficient difluoromethylenation of alkenes/alkynes and difluoromethylation of O-, S-, and N-nucleophiles.
UsesTrimethyl(bromodifluoromethyl)silane can be used as neuroactive steroids.
UsesAs reported by Hu and co-workers, (Bromodifluoromethyl)trimethylsilane is a highly useful reagent for the formation of difluoromethene-containing 3-membered rings and can also difluoromethylate heteroatoms with the assistance of alkaline bases, most effectively KOH.
Application
  • TriMethyl(broModifluoroMethyl)silane commonly can be used as a source for generating difluorocarbene, it is a general reagent with broad synthetic utility.
  • Can generate difluorocarbene under neutral/acidic/basic conditions in the presence/absence of water at low/high temperatures.
  • Can be used to prepare gem-difluorocyclopropan(e)nes, O-, S-, N-, and P-difluoromethylated compounds
Reactions (1) Difluoromethylenation of TMSCN.
TriMethyl(broModifluoroMethyl)silane
Ref. J. Org. Chem. 2012, 77, 5850?5855.
(2) Difluoromethylenation of benzyl and alkylzinc halides.
TriMethyl(broModifluoroMethyl)silane
Ref. Org. Lett. 2013, 15, 917 – 919.
(3) Fluorination aminocarbonylation of aldehydes
TriMethyl(broModifluoroMethyl)silane
Ref. Angew. Chem. Int. Ed. 2022, e202115467
General Description(Bromodifluoromethyl)trimethylsilane (TMSCF2Br) is commonly used as a source to generate dilfluorocarbene. TMSCF3 (Ruppert–Prakash reagent) and BBr3 undergoes fast halogen–exchange reaction to form MSCF2Br.
References [1]Angewandte Chemie International Edition.DOI :10.1002/anie.202283811
[2]The Journal of Organic Chemistry.DOI :10.1021/acs.orglett.2c02899
Tag:TriMethyl(broModifluoroMethyl)silane(115262-01-6) Related Product Information
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