布地奈德杂质C
| 中文名称 | 布地奈德杂质C |
|---|---|
| 中文同义词 | (4AR,4BS,5S,6AS,7AR,10AR,11AS,11BS)-4B,6,6A,7A,10A,11,11A,11B,12,13-十氢-5-羟基-7A-(羟基甲基)-4A,6A-二甲基-9-丙基-屈并[2,3-D][1,3]二氧杂环戊烯-2,7(4AH,5H)-二酮;布地奈德杂质C;布地奈德EP杂质C;布地奈德EP杂质C(D-均布地奈德);布地奈德EP杂质C(D-HOMO;布地奈德杂质C(EP);布地奈德杂质03;布地奈德C |
| 英文名称 | 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) |
| 英文同义词 | 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers);Budesonide IMpurity C;(4aR,4bS,5S,6aS,7aR,10aR,11aS,11bS)-4b,6,6a,7a,10a,11,11a,11b,12,13-Decahydro-5-hydroxy-7a-(hydroxymethyl)-4a,6a-dimethyl-9-propyl-chryseno[2,3-d][1,3]dioxole-2,7(4aH,5H)-dione;16α,17-[(1RS)-butylidenebis(oxy)]-11β-hydroxy-17-(hydroxymethyl)-D-homoandrosta-1,4-diene-3,17a-dione;16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxymethyl)-D-homoandrosta-1,4-diene-3,17a-dione \n(Mixture of Diastereomers);Budesonide Impurity 3(Budesonide EP Impurity C);Budesonide EP Impurity C;Budesonide EP Imp C |
| CAS号 | 1040085-99-1 |
| 分子式 | C25H34O6 |
| 分子量 | 430.53 |
| EINECS号 | |
| 相关类别 | 对照品-杂质对照品;杂质对照品;159-布地奈德;布地奈德杂质;Pharmaceuticals;Steroids;Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids;Impurities;Intermediates & Fine Chemicals |
| Mol文件 | 1040085-99-1.mol |
| 结构式 |  |
布地奈德杂质C 性质
| 熔点 | >98°C (dec.) |
|---|---|
| 沸点 | 607.0±55.0 °C(Predicted) |
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C Freezer |
| 溶解度 | DMSO（微溶）、甲醇（微溶、加热）、乙酸乙酯 |
| 酸度系数(pKa) | 13.77±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
Budesonide impurity C 是 Budesonide 的一种杂质。Budesonide 是一种吸入型糖皮质类固醇，一种具有口服活性的糖皮质激素受体 (glucocorticoid receptor) 激动剂。
Budesonide is selective for human glucocorticoid receptor (hGR; EC
50
=45.7 pM) over mineralocorticoid receptors (EC
50
=7,620 pM) in CV-1 cells.
Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells).