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| | Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Basic information |
| Product Name: | Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- | | Synonyms: | Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-;3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol;Janex 3;3-(6,7-dimethoxyquinazolin-4-ylamino)phenol;3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference);WHI P180;JANEX3;WHIP180;JANEX-3;WHI-P180(Janex 3);WHI-P180, >98% | | CAS: | 211555-08-7 | | MF: | C16H15N3O3 | | MW: | 297.31 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 211555-08-7.mol | ![Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Structure](CAS/20150408/GIF/211555-08-7.gif) |
| | Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Chemical Properties |
| Boiling point | 476.5±40.0 °C(Predicted) | | density | 1.336±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO : 25 mg/mL (84.09 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) | | form | Powder | | pka | 9.58±0.10(Predicted) |
| | Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Usage And Synthesis |
| Biological Activity | WHI-P180 is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively. | | in vivo | WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following iv, ip, or po administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic ip bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis. | | target | | Target | Value | RET
(Cell-free assay) | 4.5 nM | KDR
(Cell-free assay) | 66 nM |
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| | Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Preparation Products And Raw materials |
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