| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:NeuroSensor 521
CAS:1428730-05-5
Purity:>=98% (HPLC) Package:5MG Remarks:SML0871-5MG
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:NeuroSensor 521 >=98% (HPLC)
CAS:1428730-05-5
Purity:NULL Package:25mg;5mg Remarks:NULL
|
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| | 7-Diethylamino-3-formyl-4-(4’-methoxyphenyl)coumarin Basic information |
| Product Name: | 7-Diethylamino-3-formyl-4-(4’-methoxyphenyl)coumarin | | Synonyms: | 7-Diethylamino-3-formyl-4-(4’-methoxyphenyl)coumarin;NeuroSensor 521;7-(Diethylamino)-4-(4-methoxyphenyl)-2-oxo-2H-1-benzopyran-3-carboxaldehyde;NeuroSensor 521 >=98% (HPLC);2H-1-Benzopyran-3-carboxaldehyde, 7-(diethylamino)-4-(4-methoxyphenyl)-2-oxo- | | CAS: | 1428730-05-5 | | MF: | C21H21NO4 | | MW: | 351.4 | | EINECS: | | | Product Categories: | | | Mol File: | 1428730-05-5.mol |  |
| | 7-Diethylamino-3-formyl-4-(4’-methoxyphenyl)coumarin Chemical Properties |
| Boiling point | 557.2±50.0 °C(Predicted) | | density | 1.260±0.06 g/cm3(Predicted) | | storage temp. | -70°C | | solubility | DMSO: soluble10mg/mL, clear | | pka | 2.78±0.20(Predicted) | | form | powder | | color | yellow to orange |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 |
| | 7-Diethylamino-3-formyl-4-(4’-methoxyphenyl)coumarin Usage And Synthesis |
| Uses | Neurosensor 521 is a selective noradrenalin and dopamine fluorescent indicator. | | Biochem/physiol Actions | NeuroSensor 521 is a fluorescent turn-on sensor designed for the selective visualization of norepinephrine over epinephrine in fixed and live cells and the fluorescence is not affected by fixation. NeuroSensor 521 binds to all primary amines, but binds catecholamines such as dopamine and norepinephrine more tightly than other biogenic amines such as glutamate and does not interact with secondary amines such as epinephrine. Because of the spectral properties of NeuroSensor 521, the unbound and bound states can be monitored using 440 and 488 nm excitation, respectively. In chromaffin cells NeuroSensor 521 stained the norepinephrine-containing cells preferentially over epinephrine-containing cells under identical conditions. |
| | 7-Diethylamino-3-formyl-4-(4’-methoxyphenyl)coumarin Preparation Products And Raw materials |
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