| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:CP-339818
CAS:478341-55-8
Purity:>=98% (HPLC) Package:5MG Remarks:C2499-5MG
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| Company Name: |
BOC Sciences
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| Tel: |
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| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CP 339818 hydrochloride
CAS:478341-55-8
Purity:≥99% by HPLC Remarks:The hydrochloride salt form of CP 339818, a non-peptide KV1.3 channel antagonist, has been found to be more effectively than HCN4 in blocking HCN1.
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride
CAS:478341-55-8
Purity:98% Package:10mg; 50mg Remarks:Medbio
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| | N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride Basic information |
| | N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | powder | | color | white to off-white | | Water Solubility | Soluble to 20 mM in water |
| | N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride Usage And Synthesis |
| Biochem/physiol Actions | CP-338818 blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function. |
| | N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride Preparation Products And Raw materials |
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