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Cabergoline

Cabergoline Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Cabergoline
CAS:81409-90-7
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:81409-90-7
CAS:81409-90-7
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: PI & PI BIOTECH INC.
Tel: 18371201331
Email: Sales@pipitech.com
Products Intro: Product Name:Cabergoline
CAS:81409-90-7
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:(8β)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)-ergoline-8-carboxamide
Company Name: SHANDONG ZHI SHANG CHEMICAL CO.LTD
Tel:
Email: sales@sdzschem.com
Products Intro: Product Name:Cabergoline
CAS:81409-90-7
Purity:0.99 Package:5KG;1KG
Company Name: hdzhl biotechnology co., ltd
Tel: 86-13032617415
Email: sales@luchibiology.com
Products Intro: Product Name:Cabergoline
CAS:81409-90-7
Purity:0.99 Package:25kg/drum Remarks:Chemical reagents, fine chemicals, pharmaceutical intermediates, material intermediates

Lastest Price from Cabergoline manufacturers

  • Cabergoline
  • US $50.00 / Kg/Bag
  • 2021-04-28
  • CAS:81409-90-7
  • Min. Order: 100g
  • Purity: 99.5%
  • Supply Ability: 50tons
  • Cabergoline
  • US $10.00 / Kg/Drum
  • 2021-04-21
  • CAS:81409-90-7
  • Min. Order: 1BOU/Drum
  • Purity: 99%min
  • Supply Ability: 5000
  • Cabergoline
  • US $10.00 / KG
  • 2020-10-19
  • CAS:81409-90-7
  • Min. Order: 1KG
  • Purity: 99.99
  • Supply Ability: 10Ton
Cabergoline Basic information
Product Name:Cabergoline
Synonyms:6-allyl-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)ergoline-8-carboxamide;CABERGOLINE;(8b)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)- ergoline-8-carboxamide;Cabaser;Dostine;FCE-21336;C08187;Dostinex
CAS:81409-90-7
MF:C26H37N5O2
MW:451.6
EINECS:200-419-0
Product Categories:API;Neurochemicals;Intermediates & Fine Chemicals;Pharmaceuticals;PP
Mol File:81409-90-7.mol
Cabergoline Structure
Cabergoline Chemical Properties
Melting point 102-104°C
density 1.156±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMSO: ≥10mg/mL
pka13.05±0.46(Predicted)
form powder
optical activity[α]/D 61 to 68°, c = 0.5 in dichloromethane
InChIKeyKORNTPPJEAJQIU-KJXAQDMKSA-N
CAS DataBase Reference81409-90-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/37
WGK Germany 3
RTECS KE6167600
HS Code 2939690000
ToxicitySol in ethyl alcohol, chloroform, DMF; slightly sol in 0.1 N HCl; very slightly sol in n-hexane. Insol in water. LD50 orally in male mice: >400 mg/kg (Brambilla)
MSDS Information
Cabergoline Usage And Synthesis
DescriptionCabergoline is a potent, selective, and long-lasting dopamine D2 receptor agonist launched in 1993 in Belgium as a prolactin inhibitor. A single 1 mg dose of cabergoline effectively prevents puerperal lactation for up to 14 days, remarkably superior to other drugs that require a daily regimen. It has a low rate of rebound breast activity and good tolerability. Cabergoline is also in clinical trials for Parkinson's disease, breast cancer, and hyperprolactinaemia.
Chemical PropertiesWhite Crystalline Solid
Originator Kabi Pharmacia (Sweden)
UsesA dopamine D2-receptor agonist.
Usesreceptor stimulant
DefinitionChEBI: An N-acylurea that is (8R)-ergoline-8-carboxamide in which the hydrogen attached to the piperidine nitrogen (position 6) is substituted by an allyl group and the hydrogens attached to the carboxamide nitrogen are substit ted by a 3-(dimethylamino)propyl group and an N-ethylcarbamoyl group. A dopamine D2 receptor agonist, cabergoline is used in the management of Parkinson's disease and of disorders associated with hyperprolactinaemia.
Manufacturing ProcessA mixture of 6-(2-propenyl)-8β-carboxy-ergoline and N-(3- dimethylaminopropyl)-N-ethyl carbodiimide in tetrahydrofuran were refluxed, with stirring and under nitrogen, for 24 h. The resultant solution was evaporated in vacuo to dryness and the residue taken up with chloroform and 5% sodium hydroxide solution. The organic phase was separated, dried over anhydrous sodium sulfate and evaporated in vacuo. The residue was chromatographed on silica (eluant chloroform with 1% methanol) to give the title compound N-(3-(dimethylamino)propyl)-N-((ethylamino)carbonyl)-8β- carboxamide-6-(2-propenyl)ergoline.
Brand nameDostinex (Pharmacia & Upjohn).
Therapeutic FunctionProlactin inhibitor
General DescriptionCabergoline, (6aR,9R,10aR)-7-allyl-N-(3-(dimethylamino)propyl)-N-(ethylcarbamoyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide (Dostinex), is a white powder soluble inalcohol, chloroform, and N,N-dimethylformamide; slightlysoluble in acidic solutions and in n-hexane; and insoluble inwater. Following oral administration, peak plasma concentrationsare reached within 2 to 3 hours. Cabergoline ismoderately bound to plasma proteins in a concentrationindependentmanner. The absolute bioavailability of cabergolineis unknown. Cabergoline is extensively metabolizedby the liver, predominantly via hydrolysis of the acylureabond of the urea moiety. CYP450 metabolism appears to beminimal. The major metabolites identified thus far do not contribute to the therapeutic effect of cabergoline. Lessthan 4% is excreted unchanged in the urine. Fecal excretionrepresents the main route of cabergoline elimination. Thereare no reports of interactions of cabergoline with other antiparkinsonianagents. Clarithromycin may elevate theplasma concentration of cabergoline by the inhibition ofboth CYP3A4 and P-glycoprotein.Cabergoline is a potentD2 receptor agonist and is indicated for the treatment ofhyperprolactinemic disorders, either idiopathic or causedby pituitary adenomas.
Biological ActivitySelective D 2 -like dopamine receptor agonist (K i values are 0.7, 1.5, 9.0 and 165 nM for D 2 , D 3 , D 4 and D 5 receptors respectively) that also displays high affinity for several serotonin receptor subtypes (K i = 1.2-20.0 nM for 5-HT 1A , 5-HT 1D , 5-HT 2A and 5-HT 2B ). Inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys.
Veterinary Drugs and TreatmentsFor dogs, cabergoline may be useful for inducing estrus, treatment of primary or secondary anestrus, pseudopregnancy, and pregnancy termination in the second half of pregnancy. Cabergoline may be useful in treating some cases of pituitary-dependent hyperadrenocorticism (Cushing’s).
In cats, cabergoline, with or without a prostaglandin, may be useful for pregnancy termination, particularly earlier in pregnancy. Preliminary work has been done in psittacines (primarily Cockatiels) for adjunctive treatment of reproductive-related disorders, particularly persistent egg laying.
In humans, cabergoline is indicated for the treatment of disorders associated with hyperprolactenemia or the treatment of Parkinson’s disease.
Cabergoline Preparation Products And Raw materials
Raw materialsFuran-->3-METHOXYPROPIONIC ACID-->Sodium hydroxide-->1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Tag:Cabergoline(81409-90-7) Related Product Information
Cabergoline internal Spec N,N-DIMETHYL-3-PIPERIDINECARBOXAMIDE CABERGOLINE-D3 Ergoline, 8-methyl-6-(2-propenyl)-, (8-beta)- 2,6,10-TRIMETHYL-2,6,10-TRIAZAUNDECANE 1H-Indole, 4-(3-piperidinyl)-, (R)- NIPECOTAMIDE PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE N-ethylpiperidine-3-carboxamide 3,3'-IMINOBIS(N,N-DIMETHYLPROPYLAMINE) ergotamine Propyl gallate Allylbenzene Allyl alcohol Cabergoline Nicergoline Allyl glycidyl ether N,N-Dimethylformamide