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| | glucagon receptor antagonists-4 Basic information |
| Product Name: | glucagon receptor antagonists-4 | | Synonyms: | glucagon receptor antagonists-4;N-{4-[(1S)-1-{3,5-Dimethyl-4-[4-(trifluoromethyl)-1H-pyrazol-1-yl]phenoxy}butyl]benzoyl}-β-alanine;lucagon receptor antagonists-4;Glucagon Receptor Antagonist 4;GCGR-IN-17;PF06291874;PF-06291874;PF 06291874;PF6291874;CS-2641 | | CAS: | 1393124-08-7 | | MF: | C26H28F3N3O4 | | MW: | 503.51 | | EINECS: | | | Product Categories: | API | | Mol File: | 1393124-08-7.mol |  |
| | glucagon receptor antagonists-4 Chemical Properties |
| Boiling point | 675.0±55.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50mg/mL; DMSO: 50mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL; Ethanol: 0.5mg/mL | | form | A crystalline solid | | pka | 4.28±0.10(Predicted) |
| | glucagon receptor antagonists-4 Usage And Synthesis |
| Uses | PF-06291874 is a novel and potent glucagon receptor antagonist for the potential treatment of diabetes mellitus. PF-06291874, has a lower molcular weight and lipophilicity than historical glucagon receptor antagonists, resulting in excellent selectivity in broad-panel screening, lower cytotoxicity, and excellent overall in vivo safety in early pre-clinical testing. |
| | glucagon receptor antagonists-4 Preparation Products And Raw materials |
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