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| | CP 94253 hydrochloride Basic information |
| Product Name: | CP 94253 hydrochloride | | Synonyms: | 1H-Pyrrolo[3,2-b]pyridine, 5-propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-,monohydrochloride;CP94253,CP94253 hydrochloride,Serotonin Receptor,inhibit,CP 94253,CP-94253,5-hydroxytryptamine Receptor,Inhibitor,5-HT Receptor | | CAS: | 845861-39-4 | | MF: | C15H20ClN3O | | MW: | 293.8 | | EINECS: | | | Product Categories: | | | Mol File: | 845861-39-4.mol |  |
| | CP 94253 hydrochloride Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | Soluble to 25 mM in water and to 100 mM in DMSO | | form | Powder | | color | Pale yellow |
| | CP 94253 hydrochloride Usage And Synthesis |
| Description | CP 94,253 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B (Ki = 2 nM in a radioligand binding assay). It is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1C, and 5-HT2 receptors (Kis = 89, 49, 860, and 1,600 nM, respectively). CP 94,253 (10 and 17 mg/kg) reduces aggressive behavior in a resident-intruder test in mice, as well as decreases alcohol-induced aggression in mice with an ED50 value of 3.8 mg/kg. It decreases the time mice spend immobile in the forced swim test by 43%, indicating antidepressant-like activity, when administered at a dose of 5 mg/kg. CP 94,253 (2.5 mg/kg) also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats. | | Uses | CP 94253 Hydrochloride is a potent and selective serotonin 5-HT1B receptor agonist with anticonvulsant activity. | | storage | Desiccate at RT |
| | CP 94253 hydrochloride Preparation Products And Raw materials |
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