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| | FGF-401 Basic information |
| Product Name: | FGF-401 | | Synonyms: | 8-naphthyridine-1(2H)-carboxamide;0997;FGF-401;N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide;N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide;Roblitinib（FGF-401）;FGF 401;FGF-401;N-[5-Cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide | | CAS: | 1708971-55-4 | | MF: | C25H30N8O4 | | MW: | 506.56 | | EINECS: | | | Product Categories: | API | | Mol File: | 1708971-55-4.mol |  |
| | FGF-401 Chemical Properties |
| Boiling point | 852.1±65.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | pka | 11.40±0.20(Predicted) |
| | FGF-401 Usage And Synthesis |
| Description | FGF401 is an inhibitor of FGF receptor 4 (FGFR4; IC50 = 1.9 nM). It inhibits proliferation of Huh7 carcinoma cells with an IC50 value of 12 nM. FGF401 induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids when administered at a dose of 45 mg/kg per day for four weeks. It also decreases serum cholesterol when administered at doses ranging from 5 to 45 mg/kg per day. |
| | FGF-401 Preparation Products And Raw materials |
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