NS-2028

NS-2028 Suppliers list
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Email: factory@coreychem.com
Products Intro: Product Name:NS-2028
CAS:204326-43-2
Purity:99.0% Package:1KG;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:NS-2028
CAS:204326-43-2
Purity:98.00% Package:1 mL * 10mM (in DMSO);10 mg;100 mg;2 mg;200 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:NS-2028
CAS:204326-43-2
Package:100Mg,10Mg
Company Name: Chemsky(shanghai)International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:NS-2028
CAS:204326-43-2
Purity:98%
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com
Products Intro: Product Name:NS 2028
CAS:204326-43-2
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g

NS-2028 manufacturers

  • NS-2028
  • NS-2028 pictures
  • $1.00 / 1KG
  • 2020-01-19
  • CAS:204326-43-2
  • Min. Order: 1KG
  • Purity: 99.0%
  • Supply Ability: 100kg
NS-2028 Basic information
Product Name:NS-2028
Synonyms:NS-2028;8-BROMO-4H-2,5-DIOXA-3,9B-DIAZA CYCLOPENTA[A]NAPHTHALEN-1-ONE;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZ(B)(1,4)OXAZIN-1-ONE;4H-8-BROMO-1,2,4-OXADIAZOLO(3,4-D)BENZO(B)(1,4)OXAZIN-1-ONE;4-H-BROMO-1,2,4-OXADIAZOLE(3,4-ALPHA)BENZ(B)OXAZIN-1-ONE;NS 2028 - CAS 204326-43-2 - Calbiochem;8-Bromo-1H,4H-[1,2,4]Oxadiazolo[3,4-c][1,4]Benzoxazin-1-One;8-bromo-4~{H}-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
CAS:204326-43-2
MF:C9H5BrN2O3
MW:269.05
EINECS:
Product Categories:Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:204326-43-2.mol
NS-2028 Structure
NS-2028 Chemical Properties
Melting point 160~170℃
Boiling point 353.8±52.0 °C(Predicted)
density 2.06±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMSO: 13 mg/mL
pka-1.18±0.20(Predicted)
form solid
color white
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
NS-2028 Usage And Synthesis
UsesNS-2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates is inhibited by NS-2028 with an IC50 value of 17 nM, making it about 4.7 fold more potent than ODQ, which has an IC50 value of 80 nM for inhibition of soluble guanylyl cyclase in the same assay. NS-2028 does not inhibit particulate guanylyl cyclase or adenylyl cyclase.
UsesNS-2028 potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). NS-2028 blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA. NS-2028 inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).
storageStore at +4°C
NS-2028 Preparation Products And Raw materials
Tag:NS-2028(204326-43-2) Related Product Information
BAY 41-2272 GUANYLIN (HUMAN) ODQ TYRPHOSTIN AG 1288 YC-1 GUANYLIN (RAT) Protoporphyrin IX L-Carnosine 6-ANILINO-5,8-QUINOLINEDIONE 6-Bromo-4-methyl-3,4-dihydro-2H-1,4-benzoxazine NS-2028 2-(4-bromophenoxy)ethanimidamide 5-BROMO-2-METHOXYANILINE 3-BROMO-N,N-DIMETHYLANILINE