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Flomoxef

Flomoxef Suppliers list
Company Name: Hebei Yanxi Chemical Co., Ltd.
Tel: +8617531190177
Email: peter@yan-xi.com
Products Intro: Product Name:Flomoxef
CAS:99665-00-6
Purity:99 Package:1kg;0.00;USD|25kg;0.00;USD|100kg;0.00;USD
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:Flomoxef
CAS:99665-00-6
Purity:99% Package:25KG;5KG;1KG
Company Name: Shanghai Time Chemicals CO., Ltd.
Tel: +86-021-57951555 +8617317452075
Email: jack.li@time-chemicals.com
Products Intro: Product Name:Flomoxef
CAS:99665-00-6
Company Name: Nanjing Finetech Chemical Co., Ltd.
Tel: 025-85710122 17714198479
Email: sales@fine-chemtech.com
Products Intro: CAS:99665-00-6
Purity:99%min Package:1KG;10KG;100KG;500KG;100g Remarks:ISO certified
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Flomoxef
CAS:99665-00-6
Purity:99% Package:3KG;3USD

Flomoxef manufacturers

  • Flomoxef
  • Flomoxef pictures
  • $0.00 / 1kg
  • 2023-10-24
  • CAS:99665-00-6
  • Min. Order: 1kg
  • Purity: 99
  • Supply Ability: 20tons
  • Flomoxef
  • Flomoxef pictures
  • $1.00 / 1kg
  • 2022-11-23
  • CAS:99665-00-6
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 300MT/month
  • Flomoxef
  • Flomoxef pictures
  • $0.00 / 25Kg/Drum
  • 2021-11-06
  • CAS:99665-00-6
  • Min. Order: 1KG
  • Purity: 98%min
  • Supply Ability: 1000kg
Flomoxef Basic information
Product Name:Flomoxef
Synonyms:FLOMOXEF;5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)-;FLOMOXEF [5-OXA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID, 7-[[[(DIFLUOROMETHYL)THIO]ACETYL]AMINO]-3-[[[1-(2-HYDROXYETHYL)-1H-TETRAZOL-5-YL]THIO]METHYL]-7-METHOXY-8-OXO-, (6R-CIS)- ];5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, (6R,7R)-;Flumarin;FMOX;(-)-(6R,7R)-7-(2-((Difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;(6R,7R)-7α-[[(Difluoromethyl)thio]acetylamino]-7-methoxy-8-oxo-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-1-aza-5-oxabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS:99665-00-6
MF:C15H18F2N6O7S2
MW:496.47
EINECS:
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:99665-00-6.mol
Flomoxef Structure
Flomoxef Chemical Properties
Melting point 82.5-87.5°
density 1.85±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility soluble in DMSO, Methanol
form Solid
pka3.26±0.40(Predicted)
color Off-White
CAS DataBase Reference99665-00-6(CAS DataBase Reference)
Safety Information
MSDS Information
Flomoxef Usage And Synthesis
DescriptionFlomoxef sodium is a P-lactamase resistant oxacephalosporin. Its spectrum of activity is similar to that of cefazolin and moxalactam, but with better efficacy against Staphylococcus aureus and Bacteroides fragilis. Flomoxef is reported effective in the treatment of post-operative, urinary tract and abdominal cavity infections.
OriginatorShionogi (Japan)
UsesFlomoxef is an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.
DefinitionChEBI: Flomoxef is a second-generation oxacephem antibiotic in which the oxazine ring is substituted at C-3 with a hydroxyethyl-substituted tetrazolylthiomethyl group and the azetidinone ring carries 7alpha-methoxy and 7beta-{2-[(difluoromethyl)thiomethyl]acetamido} substituents. It has a role as an antibacterial drug. It is a N-acyl-amino acid, an oxacephem and an organonitrogen heterocyclic antibiotic.
Brand nameFlumari
Antimicrobial activityAn oxa-cephem which differs from latamoxef in the side chains carried at the 7-amino and C-3 positions, but which retains the 7-methoxy group that confers β-lactamase stability. The methyl group of the methylthiotetrazole side chain of latamoxef has been modified to hydroxymethyl in an attempt to avoid the undesirable side effects, while the side chain at the 7-amino position is F2-CH-S-CH2-.
Activity is similar to that of latamoxef, but activity against Staph. aureus is improved and it is claimed to be a poor inducer of penicillin-binding protein 2′, which is associated with resistance in methicillin-resistant strains.
Intravenous injection of 2 g achieves a peak plasma concentration of around 50 mg/L, falling to 2.6 mg/L after 6 h. The plasma half-life is about 50 min. It appears to be well distributed and penetrates moderately well into lung, mucosal tissue of the middle ear and bone.
Flomoxef does not seem to be prone to the effects on platelet function of latamoxef and it has a less marked effect on vitamin K metabolism. It does not cause a disulfiram-like reaction with alcohol.
It is available in Japan, where it appears safe and effective in a wide range of infections.
Flomoxef Preparation Products And Raw materials
Raw materialsEthanol-->Magnesium sulfate-->Potassium hydroxide-->Triethylamine-->Sodium chloride-->Iodomethane-->Sodium ethoxide-->ETHYL THIOGLYCOLATE
Tag:Flomoxef(99665-00-6) Related Product Information
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